UMR 1078
Genetics, functional genomics
and biotechnology

Publications de l'équipe Cancérologie Appliquée et Épissage Alternatif

Publications par année


Pour toute information sur les publications, contactez :


2015 / 2014 / 2013 / 2012 / 2011 / 2010 / 2009 / 2008 / 2006 / 2005 / 2004 / 2003 / 2002 /


  • Gattolliat CH, Uguen A, Pesson M, Trillet K, Simon B, Doucet L, Robaszkiewicz M, Corcos L. MicroRNA and targeted mRNA expression profiling analysis in human colorectal adenomas and adenocarcinomas. European Journal of Cancer, 2015 Feb;51(3):409-20


  • Dujardin G, Kornblihtt AR, Corcos L. [Kinetic regulation of pre-messenger RNA alternative splicing]. Med Sci (Paris). 2014 Nov;30(11):940-3
  • Dujardin G, Lafaille C, de la Mata M, Marasco LE, Muñoz MJ, Le Jossic-Corcos C, Corcos L, Kornblihtt AR. How slow RNA polymerase II elongation favors alternative exon skipping. Mol Cell. 2014 May 22;54(4):683-90.
  • Pesson M, Volant A, Uguen A, Trillet K, De La Grange P, Aubry M, Daoulas M, Robaszkiewicz M, Le Gac G, Morel A, Simon B, Corcos L. A gene expression and pre-mRNA splicing signature that marks the adenoma-adenocarcinoma progression in colorectal cancer. PLoS one, 2014 Feb 6;9(2):e87761
  • Pesson M, Eymin B, De La Grange P, Simon B, Corcos L. A dedicated microarray for in-depth analysis of pre-mRNA splicing events: application to the study of genes involved in the response to targeted anticancer therapies. Mol Cancer, Jan 2014, 13:9.



  •  Corcos L, Le Jossic-Corcos C. Statins: perspectives in cancer therapeutics. Dig Liver Dis. 2013 Oct;45(10):795-802.



  • Bellien J, Remy-Jouet I, Iacob M, Blot E, Mercier A, Lucas D, Dreano Y, Gutierrez L, Donnadieu N, Thuillez C, Joannides R. Impaired role of epoxyeicosatrienoic acids in the regulation of basal conduit artery diameter during essential hypertension. Hypertension. 2012 Dec;60(6):1415-21.
  • Bellien J, Iacob M, Remy-Jouet I, Lucas D, Monteil C, Gutierrez L, Vendeville C, Dreano Y, Mercier A, Thuillez C, Joannides R. Epoxyeicosatrienoic acids contribute with altered nitric oxide and endothelin-1 pathways to conduit artery endothelial dysfunction in essential hypertension. Circulation. 2012 Mar 13;125(10):1266-75.
  • Corcos L, Lucas D, Le Jossic-Corcos C, Dréano Y, Simon B, Plée-Gautier E, Amet Y, Salaün JP. Human cytochrome P450 4F3: structure, functions, and prospects. Drug Metabol Drug Interact. 2012 Apr 19;27(2):63-71.
  • Cousin FJ, Jouan-Lanhouet S, Dimanche-Boitrel MT, Corcos L, Jan G. Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells. PLoS One. 2012;7(3):e31892.
  • Follet J, Corcos L, Baffet G, Ezan F, Morel F, Simon B, Le Jossic-Corcos C. The association of statins and taxanes: an efficient combination trigger of cancer cell apoptosis. Br J Cancer. 2012 Feb 14;106(4):685-92.
  • Ianotto JC, Tempescul A, Amet Y, Grall P, Dalbies F, Eveillard JR, Guillerm G, Berthou C. Imatinib mesylate induces massive and nonspecific aminoaciduria in CML patients. Am J Hematol. 2012 Apr;87(4):437-9.
  • Merabet N, Bellien J, Glevarec E, Nicol L, Lucas D, Remy-Jouet I, Bounoure F, Dreano Y, Wecker D, Thuillez C, Mulder P. Soluble epoxide hydrolase inhibition improves myocardial perfusion and function in experimental heart failure. J Mol Cell Cardiol. 2012 Mar;52(3):660-6.
  • Plée-Gautier E, Antoun J, Goulitquer S, Le Jossic-Corcos C, Simon B, Amet Y, Salaün JP, Corcos L. Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism. Biochem Pharmacol. 2012 Aug 15;84(4):571-9.
  • Tixier F, Visvikis D, Hatt M, Corcos L, Le Rest CC. Marker Selection Based on Only Reproducibility Can Be Questioned: Reply. J Nucl Med. 2012 Oct 12.
  • Tixier F, Hatt M, Le Rest CC, Le Pogam A, Corcos L, Visvikis D. Reproducibility of tumor uptake heterogeneity characterization through textural feature analysis in 18F-FDG PET. J Nucl Med. 2012 May;53(5):693-700.



  • Dujardin G, Commandeur D, Le Jossic-Corcos C, Ferec C, Corcos L. Splicing defects in the CFTR gene: minigene analysis of two mutations, 1811+1G>C and 1898+3A>G. J Cyst Fibros. 2011 May;10(3):212-6.
  • Dutertre M, Sanchez G, Barbier J, Corcos L, Auboeuf D. The emerging role of pre-messenger RNA splicing in stress responses: sending alternative messages and silent messengers. RNA Biol. 2011 Sep-Oct;8(5):740-7.
  • Follet J, Rémy L, Hesry V, Simon B, Gillet D, Auvray P, Corcos L, Le Jossic-Corcos C. Adaptation to statins restricts human tumour growth in Nude mice. BMC Cancer. 2011 Nov 22;11:491.
  • Magne L, Blanc E, Legrand B, Lucas D, Barouki R, Rouach H, Garlatti M. ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes. J Hepatol. 2011 Apr;54(4):729-37.
  • Santigosa E, Geay F, Tonon T, Le Delliou H, Kuhl H, Reinhardt R, Corcos L, Cahu C, Zambonino-Infante JL, Mazurais D. Cloning, tissue expression analysis, and functional characterization of two Δ6-desaturase variants of sea bass (Dicentrarchus labrax L.). Mar Biotechnol (NY). 2011 Feb;13(1):22-31.
  • Tixier F, Le Rest CC, Hatt M, Albarghach N, Pradier O, Metges JP, Corcos L, Visvikis D. Intratumor heterogeneity characterized by textural features on baseline 18F-FDG PET images predicts response to concomitant radiochemotherapy in esophageal cancer. J Nucl Med. 2011 Mar;52(3):369-78.
  • Yoo BH, Wang Y, Erdogan M, Sasazuki T, Shirasawa S, Corcos L, Sabapathy K, Rosen KV. Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells. J Biol Chem. 2011 Nov 11;286(45):38894-903.



  • Dujardin G, Buratti E, Charlet-Berguerand N, Martins de Araujo M, Mbopda A, Le Jossic-Corcos C, Pagani F, Ferec C, Corcos L. CELF proteins regulate CFTR pre-mRNA splicing: essential role of the divergent domain of ETR-3. Nucleic Acids Res. 2010 Nov;38(20):7273-85.
  • Dutertre M, Sanchez G, De Cian MC, Barbier J, Dardenne E, Gratadou L, Dujardin G, Le Jossic-Corcos C, Corcos L, Auboeuf D. Cotranscriptional exon skipping in the genotoxic stress response. Nat Struct Mol Biol. 2010 Nov;17(11):1358-66.
  • Lucas D, Goulitquer S, Marienhagen J, Fer M, Dreano Y, Schwaneberg U, Amet Y, Corcos L. Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450. J Lipid Res. 2010 May;51(5):1125-33.



  • Gibot L, Follet J, Metges JP, Auvray P, Simon B, Corcos L, Le Jossic-Corcos C. Human caspase 7 is positively controlled by SREBP-1 and SREBP-2. Biochem J. 2009 May 27;420(3):473-83.
  • Lemaire-Ewing S, Berthier A, Royer MC, Logette E, Corcos L, Bouchot A, Monier S, Prunet C, Raveneau M, Rébé C, Desrumaux C, Lizard G, Néel D. 7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent. Cell Biol Toxicol. 2009 Apr;25(2):127-39.



  • Antoun J, Goulitquer S, Amet Y, Dreano Y, Salaun JP, Corcos L, Plée-Gautier E. CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis. J Lipid Res. 2008 Oct;49(10):2135-41.
  • Fer M, Corcos L, Dréano Y, Plée-Gautier E, Salaün JP, Berthou F, Amet Y. Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism. J Lipid Res. 2008 Nov;49(11):2379-89.
  • Fer M, Dréano Y, Lucas D, Corcos L, Salaün JP, Berthou F, Amet Y. Metabolism of eicosapentaenoic and docosahexaenoic acids by recombinant human cytochromes P450. Arch Biochem Biophys. 2008 Mar 15;471(2):116-25.
  • Goulitquer S, Dréano Y, Berthou F, Corcos L, Lucas D. Determination of epoxyeicosatrienoic acids in human red blood cells and plasma by GC/MS in the NICI mode. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Dec 1;876(1):83-8.
  • Kervizic G, Corcos L. Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. BMC Syst Biol. 2008 Nov 24;2:99.
  • Nguyen TA, Tychopoulos M, Bichat F, Zimmermann C, Flinois JP, Diry M, Ahlberg E, Delaforge M, Corcos L, Beaune P, Dansette P, André F, de Waziers I. Improvement of cyclophosphamide activation by CYP2B6 mutants: from in silico to ex vivo. Mol Pharmacol. 2008 Apr;73(4):1122-33. Erratum in: Mol Pharmacol. 2008 Jun;73(6):1866.
  • Solier S, De Cian MC, Bettaieb A, Desoche L, Solary E, Corcos L. PKC zeta controls DNA topoisomerase-dependent human caspase-2 pre-mRNA splicing. FEBS Lett. 2008 Jan 23;582(2):372-8.
  • Toh WH, Logette E, Corcos L, Sabapathy K. TAp73beta and DNp73beta activate the expression of the pro-survival caspase-2S. Nucleic Acids Res. 2008 Aug;36(13):4498-509.



  • Antoun J, Amet Y, Simon B, Dréano Y, Corlu A, Corcos L, Salaun JP, Plée-Gautier E. CYP4A11 is repressed by retinoic acid in human liver cells. FEBS Lett. 2006 Jun 12;580(14):3361-7.
  • Fer M, Goulitquer S, Dréano Y, Berthou F, Corcos L, Amet Y. Determination of polyunsaturated fatty acid monoepoxides by high performance liquid chromatography-mass spectrometry. J Chromatogr A. 2006 May 19;1115(1-2):1-7.
  • Meningaud JP, Pitak-Arnnop P, Corcos L, Bertrand JC. Posterior maxillary segmental osteotomy for mandibular implants placement: case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Nov;102(5):e1-3.



  • Corcos L. Regrettable omission. J Lab Clin Med. 2005 Jul;146(1):43; author reply 43.
  • Corcos L, Solier S. [Alternative mRNA splicing, pathology and molecular therapeutics]. Med Sci (Paris). 2005 Mar;21(3):253-60. Review. French.
  • Le Jossic-Corcos C, Gonthier C, Zaghini I, Logette E, Shechter I, Bournot P. Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids. Biochem J. 2005 Feb 1;385(Pt 3):787-94.
  • Tychopoulos M, Corcos L, Genne P, Beaune P, de Waziers I. A virus-directed enzyme prodrug therapy (VDEPT) strategy for lung cancer using a CYP2B6/NADPH-cytochrome P450 reductase fusion protein. Cancer Gene Ther. 2005 May;12(5):497-508.



  • Delarue J, LeFoll C, Corporeau C, Lucas D. N-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity? Reprod Nutr Dev. 2004 May-Jun;44(3):289-99. Review.
  • Desaint S, Hansmannel F, Clémencet MC, Le Jossic-Corcos C, Nicolas-Frances V, Latruffe N, Cherkaoui-Malki M. NFY interacts with the promoter region of two genes involved in the rat peroxisomal fatty acid beta-oxidation: the multifunctional protein type 1 and the 3-ketoacyl-CoA B thiolase. Lipids Health Dis. 2004 Mar 26;3:4.
  • Le Goff P, Le Dréan Y, Le Péron C, Le Jossic-Corcos C, Ainouche A, Michel D. Intracellular trafficking of heat shock factor 2. Exp Cell Res. 2004 Apr 1;294(2):480-93.
  • Le Jossic-Corcos C, Duclos S, Ramirez LC, Zaghini I, Chevillard G, Martin P, Pineau T, Bournot P. Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes. Biochim Biophys Acta. 2004 Jul 5;1683(1-3):49-58.
  • Le Jossic-Corcos C, Pastori GM, Duclos S, Kawabe Y, Pineau T, Bournot P. Peroxisome proliferator-activated receptor alpha (PPARalpha) activators induce hepatic farnesyl diphosphate synthase gene expression in rodents. J Steroid Biochem Mol Biol. 2004 Feb;88(2):203-11.Piver B, Fer M, Vitrac X, Merillon JM, Dreano Y, Berthou F, Lucas D. Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Biochem Pharmacol. 2004 Aug 15;68(4):773-82.
  • Solier S, Lansiaux A, Logette E, Wu J, Soret J, Tazi J, Bailly C, Desoche L, Solary E, Corcos L. Topoisomerase I and II inhibitors control caspase-2 pre-messenger RNA splicing in human cells. Mol Cancer Res. 2004 Jan;2(1):53-61.



  • Chen JM, Le Maréchal C, Lucas D, Raguénès O, Férec C. "Loss of function" mutations in the cationic trypsinogen gene (PRSS1) may act as a protective factor against pancreatitis. Mol Genet Metab. 2003 May;79(1):67-70.
  • González-Jasso E, López T, Lucas D, Berthou F, Manno M, Ortega A, Albores A. CYP2E1 regulation by benzene and other small organic chemicals in rat liver and peripheral lymphocytes. Toxicol Lett. 2003 Sep 15;144(1):55-67.
  • Hansmannel F, Clémencet MC, Le Jossic-Corcos C, Osumi T, Latruffe N, Nicolas-Francés V. Functional characterization of a peroxisome proliferator response-element located in the intron 3 of rat peroxisomal thiolase B gene. Biochem Biophys Res Commun. 2003 Nov 7;311(1):149-55.
  • Latruffe N, Nicolas-Francès V, Clemencet MC, Hansmannel F, Chevillard G, Etienne P, Le Jossic-Corcos C, Cherkaoui Malki M. Gene regulation of peroxisomal enzymes by nutrients, hormones and nuclear signalling factors in animal and human species. Adv Exp Med Biol. 2003;544:225-36. Review.
  • Le Gal A, Dréano Y, Lucas D, Berthou F. Diversity of selective environmental substrates for human cytochrome P450 2A6: alkoxyethers, nicotine, coumarin, N-nitrosodiethylamine, and N-nitrosobenzylmethylamine. Toxicol Lett. 2003 Sep 15;144(1):77-91.
  • Le Jossic-Corcos C, Zaghini I, Gonthier C, Logette E, Bournot P. Regulation of farnesyl diphosphate synthase gene expression by fatty acids. Adv Exp Med Biol. 2003;544:333-4.
  • Logette E, Wotawa A, Solier S, Desoche L, Solary E, Corcos L. The human caspase-2 gene: alternative promoters, pre-mRNA splicing and AUG usage direct isoform-specific expression. Oncogene. 2003 Feb 13;22(6):935-46.
  • Piver B, Berthou F, Dreano Y, Lucas D. Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. Life Sci. 2003 Jul 18;73(9):1199-213.
  • Salonen JS, Nyman L, Boobis AR, Edwards RJ, Watts P, Lake BG, Price RJ, Renwick AB, Gómez-Lechón MJ, Castell JV, Ingelman-Sundberg M, Hidestrand M, Guillouzo A, Corcos L, Goldfarb PS, Lewis DF, Taavitsainen P, Pelkonen O. Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. Drug Metab Dispos. 2003 Sep;31(9):1093-102.
  • Solary E, Bettaieb A, Dubrez-Daloz L, Corcos L. Mitochondria as a target for inducing death of malignant hematopoietic cells. Leuk Lymphoma. 2003 Apr;44(4):563-74. Review.



  • Wotawa A, Solier S, Logette E, Solary E, Corcos L. Differential influence of etoposide on two caspase-2 mRNA isoforms in leukemic cells. Cancer Lett. 2002 Nov 28;185(2):181-9.