5 thèmes de recherche inter-connectés

LBAI
Lymphocytes B et Autoimmunité
UMR 1227

Épigénétique du lymphocyte B en Auto-immunité

Collaborations:

Réseau epigenétique cancéropôle Grand ouest
Autoimmune Epigenetic task force

Publications:

Brooks WH, Renaudineau Y. Epigenetics and autoimmune diseases: The X chromosome-nucleolus nexus. Front Genet. 2015. In press.

Le Dantec C, Brooks WH, Renaudineau Y. The revolution of epigenetics. World Journal of Immunology (editorial).

Le Dantec C, Chevailler A, Renaudineau Y. Epigénétique et médecine personnalisée. Revue Francophone des Laboratoires. 2015. In press.

Le Dantec C, Vallet S, Brooks WH, Renaudineau Y. Human endogenous retrovirus group E and its involvement in diseases. Viruses. 2015. In press.

Konsta OD, Le Dantec C, Brooks WH, Renaudineau Y. Genetics and epigenetics of autoimmune diseases. eLS. 2015. In press.

Le Dantec C, Gazeau P, Mukherjee, Brooks WH, Renaudineau Y. How the environment influences epigenetics DNA methylation and autoimmune diseases. Book Epigenetics and Dermatology. 2015;2:467-487.

Konsta OD, Thabet Y, Le Dantec C, Brooks WH, Tzioufas AG, Pers JO, Renaudineau
Y. The contribution of epigenetics in Sjögren's Syndrome. Front Genet. 2014 
3;5:71. doi: 10.3389/fgene.2014.00071.

Fali T, Le Dantec C, Thabet Y, Jousse S, Hanrotel C, Youinou P, Brooks WH,
Perl A, Renaudineau Y. DNA methylation modulates HRES1/p28 expression in B cells
from patients with Lupus.
Autoimmunity. 2014 Jun;47(4):265-71. doi:
10.3109/08916934.2013.826207.

Thabet Y, Le Dantec C, Ghedira I, Devauchelle V, Cornec D, Pers JO,
Renaudineau Y. Epigenetic dysregulation in salivary glands from patients with
primary Sjögren's syndrome may be ascribed to infiltrating B cells.
J Autoimmun.
2013 Mar;41:175-81. doi: 10.1016/j.jaut.2013.02.002.

Thabet Y, Cañas F, Ghedira I, Youinou P, Mageed RA, Renaudineau Y. Altered
patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody
production: is there a link?
J Autoimmun. 2012 Sep;39(3):154-60. doi:
10.1016/j.jaut.2012.05.015.

Le Dantec C, Varin MM, Brooks WH, Pers JO, Youinou P, Renaudineau Y.
Epigenetics and Sjögren's syndrome. Curr Pharm Biotechnol. 2012
Aug;13(10):2046-53.

Renaudineau Y, Beauvillard D, Padelli M, Brooks WH, Youinou P. Epigenetic
alterations and autoimmune disease.
J Dev Orig Health Dis. 2011 Oct;2(5):258-64.
doi: 10.1017/S2040174411000353.

Renaudineau Y, Youinou P. Epigenetics and autoimmunity, with special emphasis
on methylation.
Keio J Med. 2011;60(1):10-6.

Garaud S, Youinou P, Renaudineau Y. DNA methylation and B-cell autoreactivity.
Adv Exp Med Biol. 2011;711:50-60.

Brooks WH, Le Dantec C, Pers JO, Youinou P, Renaudineau Y. Epigenetics and
autoimmunity.
J Autoimmun. 2010 May;34(3):J207-19. doi:
10.1016/j.jaut.2009.12.006.

Renaudineau Y, Garaud S, Le Dantec C, Alonso-Ramirez R, Daridon C, Youinou P.
Autoreactive B cells and epigenetics. Clin Rev Allergy Immunol. 2010
Aug;39(1):85-94. doi: 10.1007/s12016-009-8174-6.

Garaud S, Le Dantec C, Jousse-Joulin S, Hanrotel-Saliou C, Saraux A, Mageed
RA, Youinou P, Renaudineau Y. IL-6 modulates CD5 expression in B cells from
patients with lupus by regulating DNA methylation.
J Immunol. 2009 May
1;182(9):5623-32. doi: 10.4049/jimmunol.0802412.

Mankaï A, Bordron A, Renaudineau Y, Martins-Carvalho C, Takahashi S, Ghedira
I, Berthou C, Youinou P. Purine-rich box-1-mediated reduced expression of CD20
alters rituximab-induced lysis of chronic lymphocytic leukemia B cells.
Cancer
Res. 2008 Sep 15;68(18):7512-9. doi: 10.1158/0008-5472.CAN-07-6446.

Garaud S, Le Dantec C, Berthou C, Lydyard PM, Youinou P, Renaudineau Y.
Selection of the alternative exon 1 from the cd5 gene down-regulates membrane
level of the protein in B lymphocytes.
J Immunol. 2008 Aug 1;181(3):2010-8.