5 thèmes de recherche inter-connectés

LBAI
Lymphocytes B et Autoimmunité
UMR 1227

Les protocoles d’immunothérapie

Principales publications :


Pers JO, Devauchelle V, Daridon C, Bendaoud B, Le Berre R, Bordron A, et al. BAFF-modulated repopulation of B lymphocytes in the blood and salivary glands of rituximab-treated patients with Sjögren's syndrome. Arthritis Rheum 2007;56:1464-77.

Jousse-Joulin S, Devauchelle-Pensec V, Morvan J, Guias B, Pennec Y, Pers JO, et al. Ultrasound assessment of salivary glands in patients with primary Sjögren's syndrome treated with rituximab: Quantitative and Doppler waveform analysis. Biologics 2007;1:311-9.

Devauchelle-Pensec V, Cagnard N, Pers JO, Youinou P, Saraux A, Chiocchia G. Gene expression profile in the salivary glands of primary Sjögren's syndrome patients before and after treatment with rituximab. Arthritis Rheum 2010;62:2262-71.

Devauchelle-Pensec V, Morvan J, Rat AC, Jousse-Joulin S, Pennec Y, Pers JO, et al. Effects of rituximab therapy on quality of life in patients with primary Sjögren's syndrome. Clin Exp Rheumatol 2011;29:6-12.

Cornec D, Devauchelle-Pensec V, Jousse-Joulin S, Marhadour T, Ugo V, Berthou C, et al. Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy. Blood 2013;122:1583-6.

Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, Berthelot JM, Perdriger A, Puéchal X, et al. Treatment of primary Sjögren syndrome with rituximab: a randomized trial. Ann Intern Med 2014;160:233-42.

Costa S, Quintin-Roué I, Lesourd A, Jousse-Joulin S, Berthelot JM, Hachulla E, et al. Reliability of histopathological salivary gland biopsy assessment in Sjögren's syndrome: a multicentre cohort study. Rheumatology (Oxford) 2014.

Jousse-Joulin S, Devauchelle-Pensec V, Cornec D, Marhadour T, Bressollette L, Gestin S, et al. Ultrasonographic Salivary Gland Response to Rituximab in Primary Sjögren’s Syndrome. Arthritis Rheumatol 2015, in press

Cornec D, Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, Berthelot JM, Perdriger A, et al. Development of the Sjögren’s Syndrome Responder Index (SSRI), a Data-Driven Composite Endpoint for Assessing Treatment Efficacy. Rheumatology 2015, in press
 

Collaborations :

L'équipe collabore avec d’autres hôpitaux français pour les études multicentriques sur le syndrome de Gougerot-Sjögren (Rennes, Nantes, Le Mans, Paris, Strasbourg, Lille, Marseille, Rouen, Montpellier, Clermont-Ferrand…) et d’autres centres d’expertise européens (Gröningen aux Pays-Bas, Birmingham au Royaume-Uni).