Membres actuels

equipe COSM
chimie organique
santé et matériaux

CV Olivier Lozach

Lozach Olivier
Engineer CNRS
Phone : +33 (0)2 98 01 61 61
Email : olivier.lozach@
Room C117

Research interest

Keywords: Biochemistry, cellular and molecular biology, animal experiment.

- Purification, characterization and formulation of amphiphiles incorporating bio-active ingredients.
- Bio-analysis of biomolecules by HPLC-MS (Shimadzu).
- Production of in vitro bioassays (toxicity, imaging, transfection) and in vivo on animals.

Background

Engineer CNRS, Université de Bretagne Occidentale, Brest, France        since Jul 14
UMR CNRS 6521
50% in the “Phosphorus, Lipids and Vectorization” Research group, (Pr. Jaffrès Paul-Alain)
50% in the “AzaMacrocycles and Coordination” Research group, (Pr. Tripier Raphaël)

Engineer CNRS, Biological station, Roscoff, France                                 Aug 01 - Jun 14
“Protein Phosphorylation and Human Disease” Research group, USR CNRS 3151

Engineer, Plant Pathology Research group,                                                           Apr 01 - Jul 01
Bretagne Biotechnologie Végétale, Saint-Pol-de-Léon, France

Engineer assistant, Medical Biology Service,                                                           Sep 99 - Jun 01
Val-de-Grâce military hospital, Paris 5ème, France

Engineer assistant, Molecular & Development Biology,                                           Jan 99 - Jun 99
CHU Pitié-Salpêtrière, Paris 13ème, URA CNRS 2115, France

Engineer assistant, Plant Pathology Research group,                                              Jul 98 - Dec 98
Bretagne Biotechnologie Végétale, Saint-Pol-de-Léon, France

Engineer assistant, Pharmacology Research group,                                                Jan 98 - Jun 98
CHU Morvan, Brest, France

Education

Master’s degree in Biotechnology, Université d’Aix-Marseille III, France.     2001

 Others

- Correspondant security of the UMR CNRS 6521
 

 Scientific production and Conferences

80 publications in peer review journals
1 patent
1 poster in an international congress: « Natural Products with Pharmaceutical, Nutraceutical, Cosmetic, and Agrochemical Interest », 3-8 August 2008, Athens, Greece

Selected publications

A facile consensus ranking approach enhances virtual screening robustness and identifies a cell-active DYRK1α inhibitor
Mavrogeni, M. E., Pronios, F., Vasilakaki, S., Myrianthopoulos, V., Zareifi, D., Lozach, O., Alexopoulos, L., Meijer, L. and Mikros, E.
Future medicinal chemistry, 2018, 2411-2430, DOI : 10.4155/fmc-2018-0198.

Synthesis and Biological Evaluation of Bolaamphiphilic Sophorolipids
Delbeke, E. I. P., Everaert, J., Lozach, O., Le Gall, T., Berchel, M., Montier, T., Jaffres, P.-A., Rigole, P., Coenye, T., Brennich, M., Baccile, N., Roelants, S. L. K. W., Soetaert, W., Van Bogaert, I. N. A.; Van Geem, K. M. and Stevens C. V.
ACS Sustainable Chem. Eng., 2018, 7, 8992–9005, DOI : acssuschemeng.8b01354.

Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance
Myrianthopoulos, V., Lozach, O., Zareifi, D., Alexopoulos, L., Meijer, L., Gorgoulis, V. G. and Mikros, E.
Int. J. Mol. Sci., 2017, 18(10), 2102, DOI : 10.3390/ijms18102102.

Further investigation of Paprotrain: Towards the conception of selective and multi-​targeted CNS kinase inhibitors
Labriere, C., Guillou, C., Lozach O., Blairvacq M. and Meijer, L.
European journal of medicinal chemistry, 2016, 920-934, DOI : 10.1016/j.ejmech.2016.08.069.

Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors.
Ouach, A., Boulahjar, R., Vala, C., Bourg, S., Bonnet, P., Guguen-Guillouzo, C., Ravache, M., Le Guevel, R., Lozach, O., Lazar, S., Troin, Y., Meijer, L., Ruchaud, S., Akssira, M., Guillaumet, G. and Routier, S.
Eur. J. Med. Chem., 2016, 115, 311-325. DOI : 10.1016/j.ejmech.2016.02.072.

Evaluation of the transfection efficacies of quaternary ammonium salts prepared from sophorolipids.
Delbeke, E.I., Lozach, O., Le Gall, T., Berchel, M., Montier, T., Jaffrès, P.A. and, Van Geem, K.M. and Stevens, C.V.
Org. Biomol. Chem., 2016, 15, 3744-3751. DOI : 10.1039/c6ob00241b.

Lipophosphoramidate-based bipolar amphiphiles: their syntheses and transfection properties.
Berchel, M., Le Gall, T., Lozach, O., Haelters, J.P., Montier, T. and Jaffrès, P.A.
Org. Biomol. Chem., 2016, 10, 2846-2853. DOI : 10.1039/c5ob02512e.

Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors.
Boulahjar, R., Ouach, A., Bourg, S., Bonnet, P., Lozach, O., Meijer, L., Guguen-Guillouzo, C., Le Guevel, R., Lazar, S., Akssira, M., Troin, Y., Guillaumet, G. and Routier, S..
Eur. J. Med. Chem., 2015, 101, 274-287. DOI : 10.1016/j.ejmech.2015.06.046.

10-Iodo-11H-indolo[3,2-c]quinolone-6-carboxylic acids are selective inhibitors of DYRK1A.
Falke, H., Chaikuad, A., Becker, A., Loaëc, N., Lozach, O., Jhaisha, S.A., Becker, W., Jones, P.G., Preu, L., Baumann, K., Knapp, S., Meijer, L. and Kunick, C.,
J. Med. Chem., 2015, 7, 3131-3143. DOI : 10.1021/jm501994d.