equipe COSM
chimie organique
santé et matériaux

Bioconjugate Chem. , 2019


TE1PA as innovating chelator for 64Cu immuno-TEP imaging: a comparative in vivo study with DOTA/NOTA  by conjugation on 9E7.4 mAb in a syngeneic multiple myeloma model
Navarro, A-S.; Le Bihan, T.; Le Saëc, P.; Le Bris, N.; Bailly, C.; Saï-Maurel, C.; Bourgeois, M.; Chérel, M.; Tripier, R. and Faivre-Chauvet, A.
Bioconjugate Chem. , 2019, ASAP, DOI: 10.1021/acs.bioconjchem.9b00510

The higher in vivo properties of TE1PA versus DOTA for 64Cu immuno-PET imaging have been demonstrated using their bifunctional analogues p-SCN-Bn-TE1PA, p-SCN-Bn-NOTA and DOTA-NHS, conjugated with 9E7.4 rat antibody, an IgG2a anti-CD138 murine, which has relevant properties for multiple myeloma targeting.