Chemistry Eur. J. , 2019
A “Multi-Heavy-Atom” Approach Toward Biphotonic Photosensitizers With Improved Singlet Oxygen Generation Properties
Galland, M.; Le Bahers, T.; Banyasz, A.; Lascoux, N.; Duperray, A.; Grichine, A.; Tripier, R.; Guyot, Y.; Maynadier, M.; Nguyen, C.; Gary-Bobo, M.; Andraud, C.; Monnereau, C.; Maury O.
Chemistry Eur. J. , 2019, ASAP. DOI: 10.1002/chem.201901047.
The TACN based gadolinium complex exhibits high two-photon absorption cross-section combined with near-unity 1O2 generation. The very large inter system crossing efficiency induced by the combination of bromine atom and heavy rare-earth element was corroborated with theoretical calculations. The 1O2 generation properties of micellar suspensions under two-photon activation lead to tumour cells death introducing the potential of such structures for theranostic applications