Site Model

laboratoire orphy
optimisation des régulations
physiologiques

Karelle LEON

Maître de conférences en physiologie


Laboratoire de physiologie ORPHY (EA 4324), site Médecine
Université Européenne de Bretagne, Université de Brest
22 av Camille Desmoulins, CS 93837,
29238 BREST cedex 3

Tél: 02.98.01.65.66
karelle.leon@univ-brest.fr


Thématiques de recherche / compétences:

Evaluation de l’effet de cytokines et de molécules antioxydantes sur la contraction et l’excitabilité membranaire de la fibre musculaire de rat en conditions pathologiques (sepsis, inactivité).

Publications:

Derbré F, Droguet M, Léon K et al. 2016 Single muscle immobilization decreases single-fibre myosin heavy chain polymorphism. PlusONE. DOI: 10.1371/journal.pone.0158630

Talarmin H, Derbré F, Léon K et al. 2016 Diaphragm is better protected from oxidative stress than hindlimb skeletal muscle during CLP-induced sepsis. Redox Report. DOI:10.1080/13510002.2016.1223793

Léon K et al. 2015 Effect of induced mild hypothermia on acid base balance during experimental acute sepsis in rats. Ther Hypothermia Temp Manag, Vol 5:163-170

Léon K et al. 2015 Does induction time of mild-hypothermia influence the survival duration of septic rats? Ther Hypothermia Temp Manag, Vol 5:85-88

Léon K et al. 2013 Effect of mild-induced hypothermia on two proinflammatory cytokines and oxidative parameters during experimental sepsis. Redox report, Vol 18:120-126

Léon K et al. 2012 Oxygen blood transport during experimental sepsis: effect of hypothermia. Crit Care Med, Vol 40: 912-918.

Léon K et al. 2009 Effect of induced mild hypothermia upon the dynamics of sepsis progression in rat CLP model. Comp Biochem and Physiology, part A153:107-108

Hymery N, Léon K et al. 2009 T-2 toxin inhibits differentiation of human monocytes into dendritic cells and macrophages. Toxicology in Vitro, Vol 23: 509-519