laboratoire orphy
optimisation des régulations


Assistant professor, Ph.D.

EA 4324 ORPHY, Département de biologie
UFR Sciences et Techniques,
Université Européenne de Bretagne, Université de Brest
6 avenue LE GORGEU, CS 93837,
29238 BREST cedex 3
Tel: +332. / fax: +332.

Scientific scopes / competences:
Study of adaptive mechanisms developed by organisms subject to exogenous or endogenous constraints.

Partnership, financed research project:
Cèdre/TOTAL Fluid

Research project founded :
Project Région Bretagne Hemoxy-shock: Evaluation of the effectiveness of the extracellular hemoglobin from Arenicola marina as a substitute of hemoglobin in uncontrolled hemorrhagic shock in rat model

Recent publications :

Dussauze M., Milinkovitch T., Thomas-Guyon H., Danion M., Lemaire P., Pichavant-Rafini K., Theron M., Le Floch S., 2016. An Experimental System to Assess Potential Biological Impact of Operational Response During an Oil Spill. Journal of Petroleum and Environmental Biotechnology 7(3): 282. doi:10.4172/2157-7463.1000282.

Tissier F., Mallem Y., Goanvec C., Didier R., Aubry T., Bourgeois N., Desfontis J-C, Dubreuil M., Le Grand Y., Mansourati J., Pichavant-Rafini K., Plee-Gautier E., Roquefort P., Theron M., Gilard M., 2016. A non-hypocholesterolemic atorvastatin treatment improves vessel elasticity by acting on elastin composition in WHHL rabbits. Atherosclerosis 251, 70-77.

Dussauze M., Pichavant-Rafini K., Le Floch S., Marziou A., Lemaire P., Fronteau L., Belhomme M., Theron M., 2016. In vitro diving simulation : a new approach to assess biological impact of hydrocarbons at depth. Proceedings of the 39th AMOP Technical Seminar on Environmental Contamination and Response. Halifax, Canada, 7-9 June: 304-316.

Leon K., Pichavant-Rafini K., Ollivier H., Monbet V. and L'Her E. 2015. Does induction time of mild hypothermia influence the survival duration of septic rats? Therapeutic hypothermia and temperature management, 5 (2), 85-88. DOI: 10.1089/Ther.2014.0024.

Dussauze M., Pichavant-Rafini K., Le Floch S., Lemaire P. and Theron M. 2015. Acute toxicity of chemically and mechanically dispersed crude oil on juvenile sea bass (Dicentrarchus labrax): absence of synergistic effects between oil and dispersants. Environmental toxicology and chemistry, 34(7), 1543-1551.

Tissier F., Dussauze M., Lefloch N., Theron M., Lemaire P. le Floch S., Pichavant-Rafini K., 2015. Effect of dispersed crude oil on cardiac function in sea bass Dicentrarchus Labrax.Chemosphere, 134: 192-198.

Dussauze M. Danion M., Le Floch S., Lemaire P., Theron M., Pichavant-Rafini K., 2015. Growth and immune system performance to assess the effect of dispersed oil on juvenile sea bass (Dicentrarchus labrax). Ecology and Environmental Safety, 120, 215-222.

Dussauze M. Danion M., Le Floch S., Lemaire P., Pichavant-Rafini K., Theron M., 2015. Innate immunity and antioxidant systems in different tissues of sea bass (Dicentrarchus labrax) exposed to crude oil dispersed mechanically or chemically with Corexit 9500. Ecology and Environmental Safety, 120, 270-278.

Léon K., Pichavant-Rafini K., Ollivier H., L'Her E., 2015. Effect of induced mild hypothermia on acid-base balance during experimental acute sepsis in rats. Therapeutic Hypothermia and Temperature Management. Therapeutic Hypothermia and Temperature Management, 5 (3), 163-170.