Phosvec - Phosphore et vectorisation - UBO - Brest

"Phosphore et vectorisation"
de l'UMR CNRS 6521


depuis 2007

Vectorisation       Canaux ioniques      Matériaux hybrides et coordinations     

Chimie Organique                 Autres


> Publications

  Topochemical Route from Supramolecular to Hybrid Materials: Tetraphenylmethane-based Tectons and Lanthanum Phosphonate Derivative.
Pérez, O.; Bloyet, C.; Rueff, J-M.; Barrier, N.; Caignaert, V.; Jaffres, P-A. and Raveau, B.
Cryst. Growth Des., 2016, Just Accepted Manuscript, DOI: 10.1021/acs.cgd.6b00823
Published online October 31, 2016

 Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes.
Barbeau, J.; Lemiègrea L.; Quelen, A.; Malard, V.; Gao, H.; Gonçalves, C.; Berchel, M.; Jaffrès, P.A.; Pichon, C.; Midoux, P.; Benvegnua, T.
Carbohydrate Research, 2016, 435, 142–148, DOI: 10.1016/j.carres.2016.10.003.
Published online 11 October 2016

 Dimeric pyramidal Cu2O6 (H2O)2 unit – A structural invariant of a homologous series of copper-layered phosphonates.
Bloyet, C.; Roger, M.; Rueff, J.M.; Raveau, B.; Lohier, J.F.; Rogez, G.; Jaffrès, P.A.
Eur. J. Inorg. Chem., 2016, DOI: 10.1002/ejic.201600613
Published online August, 30th 2016

  Glyco-Phospho-glycero-ether lipid as modulator of SK3 ion channel and SK3-dependent cancer cell migration.
Sevrain, C. M.; Berthe, W.; Couthon-Gourvès, H.; Haelters, J.P.; Bouchet, A. M.; Potier-Cartereau, M.; Vandier, C.; Jaffrès, P.A.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, 191, DOI: 10.1080/10426507.2016.1217221.
Published online, August, 17th, 2016

Rigid phosphonic acid for the construction of crystalline organic-inorganic hybrid materials.
Roger, M.; Bloyet, C.; Evrard, Q.; Couthon-Gourvès, H.; Berchel, M.; Rueff, J.-M.; Pérez, O.; Rogez, G.; Jaffrès, P.A.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, 191, 1482-1484, DOI: 10.1080/10426507.2016.1212048.
Published online July, 22nd 2016

Synthetic phospholipids and phospho-bola-amphiphiles for nucleic acid delivery.
Berchel, M. ; Lozach, O. ; Berthe, W. ; Hernot, S. ; Couthon-Gourvès, H. ; Mottais, A. ; Le Gall, T. ; Midoux, P. ; Montier, T. ; Jaffrès, P.A.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, 191, DOI:10.1080/10426507.2016.1212049.
Published online July, 22nd, 2016.

  New disaccharides-based ether lipids for the inhibition of SK3 ion channel.
Berthe, W.; Sevrain, C.M.; Chantôme, A.; Bouchet, A.M.; Gueguinou, M.; Fourbon, Y.; Potier-Cartereau, M.; Haelters, J.P.; Couthon-Gourvès, H.; Vandier, C.; Jaffrès, P.A.
ChemMedChem, 2016, 11, 1531-1539 , DOI: 10.1002/cmdc.201600147.
Published online 9 June 2016

  Alkyl ether lipids and lipid raft reorganization in cancer therapy
Jaffrès, P.A. ; Gajate, C.; Bouchet, A.M.; Couthon-Gourvès, H.; Chantôme, A.; Potier-Cartereau, M.; Besson, P.; Bougnoux, P.; Mollinedo, F.; Vandier, C.
Pharmacology & Therapeutics, 2016, 165, 114-131, DOI: 10.1016/j.pharmthera.2016.06.003.
Published online 8 June 2016

  Triggering bilayer to inverted-hexagonal nanostructures by thiol-ene click chemistry on cationic lipids: consequences on gene transfection.
Afonso, D.; Le Gall, T.; Couthon-Gourvès, H.; Grélard, A.; Prakash, S.; Berchel, M.; Kervarec,N.; Dufourc,E.J.; Montier, T.; Jaffrès, P.A.
Soft Matter, 2016, 12, 4516-4520, DOI: 10.1039/C6SM00609D.
Published online 25 Apr 2016

 SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel apportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline.
Guéguinou, M.; Harnois, T.; Crottes, D.; Uguen, A.; Deliot, N.; Gambade, A.; Chantôme, A.; Haelters, J.P.; Jaffrès, P.A.; Jourdan, M.L.; Weber, G.; Soriani, O.; Bougnoux, P.; Mignen, O.; Bourmeyster, N.; Constantin, B.; Lecomte, T.; Vandier, C.; Potier-Cartereau, M.
Oncotarget, 2016, Vol.7, N°. 24, 36168-36184, DOI: 10.18632/oncotarget.8786.
First published online April, 18th 2016

  Evaluation of the transfection efficacies of quaternary ammonium prepared from sophorolipid.
Delbeke, E. I. P.; Lozach, O.; Le Gall, T.; Berchel, M.; Montier, T.; Jaffrès, P.-A.;  Van Geem, K.M. and Stevens, C. V.
Org. Biomol. Chem., 2016, 14, 3744-3751, DOI: 10.1039/C6OB00241B
First published online 14 Mar 2016

  Recent developments in phosphonium chemistry.
Berchel, M.; Jaffrès, P.A.
Chapitre de livre dans le livre “Organophosphorus Chemistry. From Molecules to Applications”
Edited by V. Iaroshenko, John Wiley & Sons, Inc. Published, accepté

  Lipophosphoramidates-based bipolar amphiphiles: syntheses and transfection properties.
Berchel, M.; Le GAll, T.; Lozach, O.; Haelters, J-P.; Montier, T.; Jaffres P-A.
Org. Biomol. Chem., 2016, 14, 2846-2853, DOI:10.1039/C5OB02512E.
First published online 01 Feb 2016

  Copper–Fluorenephosphonate Cu­(PO3-C13H9)·H2O: A Layered Antiferromagnetic Hybrid
Hugot, N.; Roger, M.; Rueff, J-M.; Cardin, J.; Perez, O.; Caignaert, V.; Raveau, B.; Rogez, G.; Jaffrès, P-A.
European Journal of Inorganic Chemistry, 2016, 2, 266-271 DOI: 10.1002/ejic.201501041
Article first published online: 2 DEC 2015

Important role of phosphoramido linkage in imidazole-based dioleyl helper lipids for liposome stability and primary cell transfection
Mével, M.; Haudebourg, T.; Peuziat, P.; Dallet, L.; Chatin, B.; Lambert, O.; Berchel, M.; Montier, T.; Jaffrès, P-A.; Lehn, P.; Pitard, B.
The journal of gene medicine, 2016, 18, 3-15, DOI: 10.1002/jgm.2869.

Hydrothermal synthesis for new multifonctional materials: A few examples of phosphates and phosphonate-based hybrid materials
Rueff, J.M. ; Poienar M.; Guesdon A.; Martin C.; Maignan A.; Jaffrès, P.A.
Journal of Solid State Chemistry, 2016, 236, 236-245, DOI: 10.1016/j.jssc.2015.09.018.
Available online 21 September 2015


> Publications

Evaluation of New Fluorescent Lipophosphoramidates for Gene Transfer and Biodistribution Studies after Systemic Administration
Belmadi, N.; Berchel, M; Denis, C.; Berthe, W.; Sibiril, Y.; Le Gall, T.; Haelters, J-P.; Jaffrès, P-A.; Montier, T.
International Journal of Molecular Sciences, 2015, 16 (11), 26055-26076, DOI:10.3390/ijms161125941 (registering DOI)

Liposome-based Formulation for Intracellular Delivery of Functional Proteins
Chatin B., Mével M.; Devallière J.; Dallet L.; Haudebourg T.; Peuziat P.; Colombani T.; Berchel M.; Lambert O.; Edelman A.; Pitard B.
Molecular Therapy Nucleic Acids, 2015, 4, e244, DOI:10.1038/mtna.2015.17.

  Biophysical properties of cationic lipophosphoramidates: Vesicles morphology, bilayer hydration and dynamics.
Loizeau D.; Jurkiewicz P.; Aydogan G.; Philimonenko A., Mahfoudhi S.; Hozak P.; Maroto A.; Couthon-Gourvès H.; Jaffrès P.-A.; Deschamps L.; Giamarchi P.; Hof M.
Colloids and Surfaces B: Biointerfaces, 2015, 136 , 192-200. DOI: 10.1016/j.colsurfb.2015.09.012.

Synthetic vectors for gene delivery: An overview of their evolution depending on routes of administration.
By Belmadi N.; Le Gall.; Lehn P.; Midoux P.; Pichon C.; Loyer P.; Le Gall Tony; Jaffres P.-A.; Montier T.
Biotechnology journal, 2015, 10 (9), 1370-1389. DOI: 10.1002/biot.201400841.

Enhanced achilles tendon healing by fibromodulin gene transfer.
Delalande, A.; Gosselin, M.P.; Suwalski, A.; Guilmain, W.; Leduc, C.; Berchel, M.; Jaffrès, P.A.; Baril, P.; Midoux, P.; Pichon, C.
Nanomedicine : NBM, 2015, 11 (6), 1735-1744. DOI: 10.1016/j.nano.2015.05.004.

Cationic lipophosphoramidates containing a hydroxylated polar headgroup for improving gene delivery.
Berchel, M.; Le Gall, T.; Haelters J.P.; Montier, T.; Jaffrès, P.A.
Mol. Pharmaceutics, 2015, 12 (6), 1902-1910, DOI: 10.1021/mp500807k.

Synthesis of lipid-based unsymmetrical O,O-dialkylphosphites.
Berchel, M. ; Haddad, J. ; Le Corre, S. ; Haelters, J.P. ; Jaffrès, P.A.
Tetrahedron Letters, 2015, 56, 2345-2348, DOI: 10.1016/j.tetlet.2015.03.093.

Efficient in vivo transfection and safety profile of a CpG-free and codon optimized luciferase plasmid using a cationic lipophosphoramidate in a multiple intravenous administration procedure
Lindberg, M.F. ; Le Gall, T. ; Carmoy, N. ; Berchel, M. ; Hyde, S.C. ; Gill, D.R. ; Jaffrès, P.A. ; Lehn, P. ; Montier, T.
Biomaterials, 2015, 59, 1-11, DOI: 10.1016/j.biomaterials.2015.04.024.

Silver-based hybrid materials from meta or para phosphonobenzoic acid: Influence of the topology on silver release in water.
Rueff, J.M. ; Perez, O. ; Caignaert, V. ; Hix, G. ; Berchel, M. ; Quentel, F. ; Jaffrès, P.A.
Inorg. Chem., 2015, 54, 2152-2159, DOI: 10.1021/ic502395s

  Rigid phosphonic acids as building blocks for crystalline hybrid materials.
Rueff, J.M. ; Hix, G.B. ; Jaffrès, P.A.,
Book chapter in “Tailored Organic–Inorganic Materials”, First Edition, chapter 9, p341-393.
Edited by Ernesto Brunet, Jorge L. Colón, A. Clearfield, 2015 John Wiley & Sons, Inc. Published 2015 by John Wiley & Sons, Inc. (ISBN: 978-1-118-77346-8).

Cationic dialkylarylphosphates: new family of bio-inspired cationic lipids for gene delivery.
S. S. Le Corre, N. Belmadi, M. Berchel, T. Le Gall, J.P. Haelters, P. Lehn, T. Montier, P.A. Jaffrès
Org. Biomol. Chem., 2015, 13, 1122-1132, DOI: 10.1039/c4ob01770f.

La1-xLnxH(O3PCH3)2 (Ln=Tb, Eu ; 0<x≤1) : An Organic-Inorganic Hybrid with Lanthanide Chains and Tunable Luminescent Properties.
Muteleta, B. ; Boudin, S. ; Perez, O. ; Rueff, J.M. ; Labbé, C. ; Jaffrès, P.A.
Dalton Trans., 2015, 44, 1186-1192, DOI: 10.1039/c4dt02643h.

> Thèse


> Publications

Cationic trialkylphosphates: synthesis and transfection efficacies compared to phosphoramidate analogues
S. Le Corre, M. Berchel, T. Le Gall, J.P. Haelters, P. Lehn, T. Montier, P.A. Jaffrès
Eur. J. Org. Chem., 2014, 2014 (36), 8041-8048, DOI: 10.1002/ejoc.201403103.

Effects of a Novel Archaeal Tetraether-based Colipid on the In Vivo Gene Transfer Activity of Two Cationic Amphiphiles
Le Gall, T.; Barbeau, J.; Barrier, S.; Berchel, M.; Lemiègre, L.; Jeftic, J.; Meriadec, C.; Artzner, F.; Gill, D.; Hyde, S.; Férec, C.; Lehn, P.; Jaffrès, P.A.; Benvegnu, T.; Montier, T.
Mol. Pharm., 2014, 11, 2973-2988, DOI: 10.1021/mp4006276.

Atherton-Todd Reaction: Mechanism, Scope, and Applications.
Le Corre, S.S. ; Berchel, M. ; Couthon-Gourvès, H. ; Haelters, J.P. ; Jaffrès, P.A.
Beilstein J. Org. Chem. (article on invitation), 2014, 10, 1166-1196, DOI: 10.3762/bjoc.10.117.

Functionalized Phospholipid Molecular Platform: Use for Production of Cationic Fluorescent Lipids.
Berchel, M.; Haelters, J.P.; Afonso, D.; Maroto, A.; Deschamps, L.; Giamarchi P.A. Jaffrès, P.A.
Eur. J. Org. Chem., 2014, 1076-1083, DOI: 10.1002/ejoc.201301416.

Cationic lipophosphoramidates with two different lipid chains: synthesis and evaluation as gene carriers.
Le Corre, S.S. ; Berchel, M. ; Belmadi, N. ; Denis, C. ; Haelters, J.P. ; Le Gall, T. ; Lehn, P. ; Montier, T. ; Jaffrès, P.A.
Org. Biomol. Chem., 2014, 12, 1463-1474, DOI: 10.1039/c3ob42270d.

Lipopolyplexes comprising imidazole/imidazolium lipophosphoramidate, histidinylated polyethyleneimine and siRNA as efficient formulation for siRNA transfection. Goncalves, C. ; Berchel, M. ; Gosselin, M.P. ; Malard, V. ; Cheradame, H. ; Jaffrès, P.A. ; Guégan, P. ; Pichon, C. ; Midoux, P.
Int. J. Pharm., 2014, 460, 1-2, 264-272, DOI: 10.1016/j.ijpharm.2013.11.005.

> These


> Publications

Pivotal role of the lipid raft SK3-Orai1 complex in human cancer cell migration and bone metastases
Chantôme, A.; Potier-Cartereau, M.; Clarysse, L.; Fromont, G.; Marionneau-Lambot, S.; Guéguinou, M.; Pagès, J.C.; Collin, C.; Oullier, T.; Girault, A.; Arbion, F.; Haelters, J.P.; Jaffrès, P.A.; Pinault, M.; Besson, P.; Joulin, V.; Bougnoux, P.; Vandier, C.
Cancer Research, 2013, 73, 4852-61, DOI: 10.1158/0008-5472.CAN-12-4572

DiGalactosyl-Glycero-Ether Lipid: synthetic approaches and evaluation as SK3 channel inhibitor
Sevrain, C.M., Haelters, J.P.; Chantôme, A.; Couthon-Gourvès, H.; Gueguinou, M.; Potier-Cartereau, M.; Vandier, C.; Jaffrès, P.A.
Org. Biomol. Chem., 2013, 11, 4479-4487, DOI 10.1039/c3ob40634b.

Arsonium-containing Lipophosphoramides, Poly-functional Nano-carriers for Simultaneous Antibacterial Action and Eukaryotic Cell Transfection
Le Gall, T.; Berchel, M.; Le Hir, S.; Fraix, A.; Salaün, J.Y.; Férec, C.; Lehn, P.; Jaffrès, P.A.; Montier, T.
Adv. Healthcare Mater, 2013, 2, 1513-1524, DOI: 10.1002/adhm.201200478.

Physicochemical properties of cationic lipophosphoramidates with an arsonium head group and various lipid chains: A structure-activity approach.
Loizeau, D.; Le Gall, T.; Mahfoudhi, S.; Berchel, M.; Maroto, A.; Yaouanc, J.J. ; Jaffrès, P.A.; Lehn, P.;Deschamps, L.; Montier, T.; Giamarchi, P.
Biophys. Chem., 2013, 171, 46-53, DOI: 10.1016/j.bpc.2012.10.003

Cationic lipophosphoramidates with two disulfide motifs: synthesis, behaviour in reductive media and gene transfection activity
Fraix, A.; Le Gall, T.; Berchel, M.; Denis, C.; Lehn, P. ; Montier, T. ; Jaffrès, P.A.
Org. Biomol. Chem., 2013, 11, 1650-1658, DOI: 10.1039/c3ob27261c.

> These


> Publications

Glyco-Phospho-Glycero Ether Lipid (GPGEL): synthesis and evaluation as Small Conductance Ca2+-Activated K+ Channels (SK3) inhibitor.
Sevrain, C.M. ; Haelters, J.P. ; Chantôme, A.; Couthon-Gourvès, H.; Girault, A.; Vandier, C.; Jaffrès, P.A.
MedChemComm., 2012, 3, 1471-1478, DOI: 10.1039/C2MD20207G.

Structural study of hydrated/dehydrated Manganese Thiophene-2,5-diphosphonate Metal Organic Frameworks, Mn2(O3P-C4H2S-PO3).nH2O.
Rueff, J.M.; Perez, O.; Pautrat, A.; Barrier, N.; Hix, G.; Hernot, S.; Couthon-Gourvès, H.; Jaffrès, P.A
Inorg. Chem., 2012, 51, 10251-10261, DOI: 10.1021/ic301187y.

The gene transfection properties of a lipophosphoramidate derivative with two phytanyl chains
Lindberg, M.; Carmoy, N. ; Le Gall, T.; Fraix, A.; Berchel, M. ; Lorilleux, C.; Couthon-Gourvès, H. ; Bellaud, P. ; Fautrel, A. ; Jaffrès, P.A.; Lehn, P.; Montier, T.
Biomaterials, 2012, 33, 6240-6253, DOI: 10.1016/j.biomaterials.2012.05.014.

Copper(II) n-alkylphosphonates used as nanofiller: single crystal, powder structure studies and influence of the alkyl chain length on the magnetic properties.
Chausson, S. ; Rueff, J.M.; Lepetit, M.B.; Perez, O.; Retoux, R.; Simon, Le Pluart, L.; Jaffrès, P.A.
Eur. J. Inorg. Chem., 2012, 2193-2202, DOI : 10.1002/ejic.201101218.

Gene transfer by chemical vectors: Comparative study of the endocytosis routes of polyplexes, lipoplexes and lipopolyplexes in a myoblast cell line.
Billiet, L.; Gonçalves, C.; Gomez, J.P.; Lodewick, J.; Berchel, M.; Jaffrès, PA.; Montier, T.; Lehn, P.; Bertrand, E.; El-Ghoul, Y.; Cheradame, H.; Guégan, P.; Mével, M.; Pitard, B.; Benvegnu, T.; Pichon, C.; Midoux P.
Biomaterials, 2012, 33, 2980-2990, DOI: 10.1016/j.biomaterials.2011.12.027.

Targeting SKCa Channels in Cancer: Potential New Therapeutic Approaches.
Girault, A. ; Haelters, J.P. ; Potier-Cartereau, M. ; Chantome, A. ; Jaffrès, P.A ; Bougnoux, P. ; Joulin, V. ; Vandier, C.
Curr. Med. Chem., 2012, 19, 697-713 (Review), DOI: 10.2174/092986712798992039.

Gene transfer by histidylated lipopolyplexes: A dehydration method allowing preservation of their physicochemical parameters and transfection efficiency
Perche, F.; Lambert, O.; Berchel, M.; Jaffrès, P.A.; Pichon, C.; Midoux, P.
Int. J. Pharm., 2012, 423, 144-150, DOI: 10.1016/j.ijpharm.2011.04.009.

Lipothiophosphoramidates for gene delivery: critical role of the cationic polar headgroup.
Fraix, A.; Montier, T.; Le Gall, T.; Sevrain, C.; Carmoy, N.; Lindberg, M.; Lehn, P.; Jaffrès, P.A.
Org. Biomol. Chem., 2012, 10, 2051-2058, DOI: 10.1039/c2ob06812e.

Synthesis of lipophosphoramidyl-cyclodextrins and their supramolecular properties.
Gervaise, C. ; Bonnet, V. ; Wattraint, O. ; Aubry, F. ; Sarazin, C. ; Jaffrès, P.A. ; Djedaïni-Pilard, F.
Biochimie, 2012, 94, 66-74, DOI: 10.1016/j.biochi.2011.09.005.

Lipophosphonate/lipophosphoramidates: a family of synthetic vectors efficient for gene delivery.
Berchel,M.; Le Gall,T.; Couthon-Gourvès,H. ; Haelters, J.P. ; Montier, T. ; Midoux, P. ; Lehn, P. ; Jaffrès, P.A.
Biochimie, 2012, 94, 33-41 (Review), DOI: 10.1016/j.biochi.2011.07.026.


> Publications

New Alkyl-Lipid Blockers of SK3 Channels Reduce Cancer Cell Migration and Occurence of Metastasis.
Girault, A. ; Haelters, J.P. ; Potier, M. ; Chantôme, A. ; Pineau, M. ; Marionneau-Lambot, S. ; Oullier, T. ; Simon, G. ; Couthon-Gourvès, H. ; Jaffrès, P.A. ; Joulin, V. ; Corbel, B. ; Bougnoux, P. ; C. Vandier, C.
Current Cancer Drug Target, 2011, 11, 1111-1125, DOI: 10.2174/156800911798073069.

A silver-based Metal Organic Framework material as a ‘reservoir’ of bactericidal metal ions.
Berchel, M. ; Le Gall, T. ; Denis, C. ; Le Hir, S. ; Quentel, F. ; Elléouet, C. ; Montier, T. ; Rueff, J.M. ; Salaün, J.Y. ; Haelters, J.P. ; Lehn, P. ; Hix, G.B. ; Jaffrès, P.A.
New J. Chem., 2011, 35, 1000-1003, DOI: 10.1039/C1NJ20202B.

Modular construction of fluorescent lipophosphoramidates by click chemistry.
Berchel, M. ; Haelters, J.P. ; Couthon-Gourvès, H. ; Deschamps, L. ; Midoux, P. ; Lehn, P. ; Jaffrès, P.A.
Eur. J. Org. Chem., 2011, 6294-6303, DOI: 10.1002/ejoc.201100900.

Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA.
Perche, F. ; Benvegnu, T.; Berchel, M. ; Lebegue, L. ; Pichon, C. ; Jaffrès, P.A. ; Midoux P.
Nanomedicine: NBM 2011, 7, 445-453, DOI: 10.1016/j.nano.2010.12.010.

Selective gene delivery in dendritic cells with Mannosylated and Histidylated Lipopolyplexes.
Perche, F. ; Gosset, D. ; Mével, M. ; Miramon, M.L. ; Yaouanc, J.J. ; Pichon, C. ; Benvegnu, T. ; Jaffrès, P.A. ; Midoux P.
J. Drug Targeting, 2011, 19, 315-325, DOI: 10.3109/1061186X.2010.504262.

Cationic Lipothiophosphoramidates for in vitro gene delivery: synthesis, physico-chemical characterizations and transfection assays- comparison with lipophosphoramidates.
Fraix, A. ; Montier, T. ; Carmoy, N. ; Loizeau, D. ; Burel-Deschamps, L. ; Le Gall, T. ; Giamarchi, P. ; Couthon-Gourvès, H. ; Haelters, J.P. ; Lehn, P. ; Jaffrès, P.A.
Org. Biomol. Chem., 2011, 9, 2422-2432, DOI: 10.1039/C0OB00981D.


> Publications

Unexpected [1,4]-base induced phospho-Fries rearrangement.
Berchel, M. ; Salaün, J.Y. ; Couthon-Gourvès, H. ; Haelters, J.P. ; Jaffrès, P.A.
Dalton Trans., 2010, 39, 11314-11316, DOI: 10.1039/C0DT00880J.

Highly efficient gene transfer into hepatocyte-like HepaRG cells: new means for drug metabolism and toxicity studies.
Laurent, V. ; Fraix, A. ; Montier, T. ; Cammas-Marion, S. ; Ribault, C. ; Benvegnu, T. ; Jaffrès, P.A. ; Loyer, P.
Biotechnology J., 2010, 5, 314-320, DOI: 10.1002/biot.200900255.

Construction of S,N,S monoanionic Pincer ligand with a pyrrole core by sequential [1,2] phospho-fries rearrangement. Characterization of palladium and silver coordination complexes.
Fraix, A. ; Lutz, M. ; Spek, A.L. ; Klein Gebbink, R.J.M. ; van Koten, G. ; Salaün, J.Y. ; Jaffrès, P.A.
Dalton Trans., 2010, 39, 2942-2946, DOI: 10.1039/b923351b.

DODAG; A Versatile New Cationic Lipid that Mediates Efficient Delivery of pDNA and siRNA.
Mevel, M.; Kamaly, N.; Carmona, S.; Oliver, M.H.; Jorgensen, M.R.; Crowther, C.; Salazar, F.H.; Marion, P.L.; Fujino, M.; Natori, Y.; Arbuthnot, P.; Yaouanc, J.J.; Jaffrès, P.A. ;.Miller, A. D.
J. Control Release, 2010, 143, 222-232, DOI: 10.1016/j.jconrel.2009.12.001.

A novel cationic lipophosphoramidate with di-unsaturated lipid chains : synthesis, physico-chemical and transfection activities.
Le Gall, T. ; Loizeau, D. ; Picquet, E. ; Carmoy, N. ; Yaouanc, J.J. ; Deschamps, L. ; Delépine, P. ; Giamarchi, P. ; Jaffrès, P.A. ; Lehn, P. ; Montier T.
J. Med. Chem. 2010, 53, 1496-1508, DOI: 10.1021/jm900897a.

> Brevets

Thiophosphoramidates : une nouvelle famille de lipides pour la vectorisation d’acides nucléiques
A. Fraix, T. Montier, P. Lehn, P.A. Jaffrès
Brevet U.S., 2010, N° 61/389,959 ; Patent PCT/EP2011/067423

Construction modulaire de lipides fluorescents et de lipides fluorescents ciblants
M. Berchel, J.P. Haelters, H. Couthon-Gourvès, P.A. Jaffrès
Brevet U.S., 2010, 15-07-2010, US 61/363,032 ; PCT/EP2011/061788

Composés modulateur de l’activité du canal SK3 – action antimétastatique
J.P. Haelters, B. Corbel, G. Simon, C. Vandier, M. Potier, V. Joulin, P. Bougnoux. EP10305169.4

> These

Synthèse, caractérisation et formulation de nouveaux vecteurs phospholipidiques soufrés pour une application en transfert de gènes. Fraix Aurore


> Publications

3,5-diphosphonobenzoic acid : a new rigid hetero-trifunctional building bloc to design Metal Organic Framework. Illustration with the chararacterization of Cu5[(O3P)2-C6H3-CO2]2(H2O)6.
Rueff, J.M. ; Perez, O. ; Simon, C ; Couthon-Gourvès, H. ; Lorilleux, C. Jaffrès, P.A.
Cryst. Growth Des. 2009, 9, 4262-4268, DOI: 10.1021/cg900811k.

Remarkable thermal stability of Eu(4-phosphonobenzoate): Structure investigations and luminescence properties.
Rueff, J.M. ;. Barrier, N. ; Boudin, S. ; Dorcet, V. ; Caignaert, V ; Boullay, P. ; Hix, G.B. ; Jaffrès P.A.
Dalton Trans., 2009, 10614-10620, DOI: 10.1039/b913590c.

Application of a base-induced [1,2]-rearrangement to synthesize bidentate S(sp2)-N monoanionic ligands : Characterization of Silver and Palladium complexes.
Marie, S. ; Lutz, M. ; Spek, A.L. ; Klein Gebbink, R.J.M. ; van Koten, G. ; Kervarec, N. ; Michaud, F. ; Salaün, J.Y. ; Jaffrès, P.A.
J. Organomet. Chem. 2009, 694, 4001-4007, DOI: 10.1016/j.jorganchem.2009.08.035.

Lead (II) hybrid materials from 3- or 4- phosphonobenzoic acid.
Rueff, J.M.; Perez, O. ; LeClaire, A., Couthon-Gourvès, H.; Jaffrès, P.A.
Eur. J. Inorg. Chem. 2009, 4870-4876, DOI: 10.1002/ejic.200900430.

Chemical vectors for gene delivery: A Current Review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers.
Midoux, P.; Pichon, C. ; Yaouanc, J.J ; Jaffrès, P.A.
Br. J. Pharmacol. 2009, 157, 166-178. (review), DOI: 10.1111/j.1476-5381.2009.00288.x.

Elaboration and characterization of novel PA12/layered titanoniobates nanocomposites.
Chausson, S.; Retoux, R.; Rueff, J.M.; Le Pluart, L.; Madec, P.J.; Jaffrès, P.A.
J. Mater. Res., 2009, 24, 3358-3371, DOI: 10.1557/jmr.2009.0410.

Modeling [FeFe] hydrogenase: Synthesis and protonation of a diiron dithiolate complex containing a phosphine-N-heterocyclic-carbene ligand.
Morvan, D. ; Capon, J.F. ; Gloaguen, F. ; Pétillon, F.Y. ; Schollhammer, P. ; Talarmin, J. ; Yaouanc, J.J. ; Michaud, F. ; Kervarec, N.
J. Organomet. Chem., 2009, 694, 2801-2807, DOI: 10.1016/j.jorganchem.2009.01.018

Synthesis of phosphorus-containing chitosan derivatives.
Lebouc, F. ; Dez, I. ; Gulea, M. ; Madec, P.J. ; Jaffrès, P.A.
Phoshorus, Sulfur Silicon Relat. Elem., 2009, 184, 872-889 (Publication on invitation), DOI: 10.1080/10426500802715585

Meta-phosphonobenzoic acid and copper(II) as precursors of helical chain and lamellar hybrid materials.
Rueff, J.M. ; Caignaert, V. ; Leclaire, A. ; Simon, C. ; Haelters, J.P. ;. Jaffrès, P.A.
CrystEngComm, 2009, 11, 556-559, DOI: 10.1039/B816132C.

Magnetic Bistability and Thermochromism in a Molecular CuII Chain.
Setifi,, F.; Benmansour, S.; Marchivie, M.; Dupouy, G.; Triki, S. ; Sala-Pala, J. ; Salaun, J.Y.; Gomez-Garcia C.J. Pillet, S.; Lecomte, C.; Ruiz E.
Inorg. Chem. 2009, 48, 1269-1271, DOI: 10.1021/ic802292s.

The dimeric unit [La(H2O)4(m-PO3C6H4COOH)(m-PO2(OH)C6H4COOH)(m-PO(OH)2C6H4COOH)]2 as building block of layered hybrid material.
Rueff, J.M. ; Leclaire, A. ; Jaffrès, P.A.
Solid State Sciences, 2009, 11, 812-817, DOI:10.1016/j.solidstatesciences.2008.12.008.

Synthesis of methylene diphosphonates from carbon disulfide and phosphites via desulfurization: a mechanistic study.
Heuzé, B. ; Lemarié, M. ; Vazeux, M. ; Gulea, M. ; Masson, S. ; Sene, A. ; Jaffrès, P.A., Alberti A., Macciantelli D.
Phoshorus, Sulfur Silicon Relat. Elem., 2009, 184, 820-829. (Publication on invitation), DOI:10.1080/10426500802715528.

Phosphine Addition to Pyruvoyl Ligands of Iron Complexes; Formation of Zwitterionic Metallalactones.
Salaün, J.Y. ; Rumin, R. ; Setifi, F. ; Triki, S. ; Jaffrès, P.A.
Organometallics, 2009, 28, 216-224, DOI: 10.1021/om800804b.


> Publications

Synthesis of O,O-Diethyl arylthiophosphonate from O-Aryl-O,O-diethylthiophosphate”
Dieng, T. ; Fraix, A. ; Salaün, J.Y. ; Dez, I. ; Klein Gebbink, R.J.M. ; van Koten, G. ; Jaffrès, P.A.
Synlett, 2008, 3121-3124.

TEM/SEM Characterisation of hybrid titanoniobiates used as fillers for thermoplastic nanocomposites
Retoux, R. ; Chausson, S., Le Pluart, L. ; Rueff, J.M., Jaffrès, P.A.
EMC2008 Vol. 2, S. Richter & A. Schwedt Editors, Springers, 2008, 785-786, DOI: 10.1007/978-3-540-85226-1_393. 

“A novel polynitrile ligand with different coordination modes: Synthesis, structure and magneticproperties of the series [M(tcnoprOH)2(H2O2)2] (M= Mn, Co and Cu) (tcnoprOH- = [(NC)2CC(OCH2CH2CH2OH)C(CN)2]-)"
Benmansour, S. ; Setifi, F. ; Gomez Garcia, C.J.; Triki, S. ; Coronado, E. ; Salaün, J.Y.
J Mol. Struct. 2008 (N° special dédié à Cotton), 890, 255-262, DOI:10.1016/j.molstruc.2008.04.044.

The Key Role of the Intermolecular π−π Interactions in the Presence of Spin Crossover in Neutral [Fe(abpt)2A2] Complexes (A = Terminal Monoanion N Ligand)
Dupouy, G. ; Marchivie, M. ; Triki, S. ; Sala-Pala, J. ; Salaün, J.Y. ; Gómez-García,C.J. ; Guionneau, P.
Inorg Chem. 2008, 47, 8921–8931, DOI: 10.1021/ic800955r.

New planar polynitrile dianion and its first coordination polymer with unexpected Short M…M contacts (tcno2-= [(NC)2CC(O)C(CN)2]2-).
Atmani, C. ; Setifi, F. ; Benmansour, S. ; Triki, S. ; Marchivie, M. ; Salaün, J.Y. ; Gómez-García, C.J.
Inorg Chem.Commun. 2008, 11, 921-924, DOI:10.1016/j.inoche.2008.04.038.

"Progress in cationic lipid-mediated gene transfection: a series of bio-inspired lipids as an example"
Montier, T. ; Benvegnu, T. ; Jaffrès, P.A.; Yaouanc, J.J.; Lehn, P.
Curr. Gene Ther., 2008, 8, 296-312. (Review), DOI: 10.2174/156652308786070989.

Meta-phosphonobenzoic acid: a rigid bifunctional precursor for the design of hybrid materials
Rueff, J.M.; Caignaert, V.; Chausson, S.; Leclaire, A.; Simon, C.; Perez, O.; le Pluart, L.; Jaffrès, P.A.
Eur. J. Inorg. Chem., 2008, 4117-4125, DOI: 10.1002/ejic.200800483.

"(N,N) versus (N,S) chelation of palladium in asymmetric allylic substitution using bis(thiazolines) ligands; a theoretical and experimental study “
Betz, A. ; Yu, Y. ; Reiher, M. ; Gaumont, A.C. ; Jaffrès, P.A. ; Gulea, M.
J. Organomet. Chem., 2008, 693, 2499-2508, DOI:10.1016/j.jorganchem.2008.04.044.

Synthesis of functionalised alkoxyalkylidene gem-bisphosphonates
Haelters, J.P. ; Couthon-Gourvès, H. ; Le Goff, A. ; Simon, G. ; Corbel, B. ; Jaffrès, P.A.
Tetrahedron, 2008, 64, 6537-6543, DOI: 10.1016/j.tet.2008.04.052.

Novel neutral imidazole-lipophosphoramides for transfection assays.
Mével, M. ; Neveu, C. ; Gonçalves, C. ; Yaouanc, J. J. ; Pichon C., Jaffrès, P. A. Midoux P,
ChemCommun, 2008, 3124-3126, DOI: 10.1039/B805226C.

An efficient and straightforward access to sulfur substituted [2.2]paracyclophanes: application to stereoselective Sulfenate Salt Alkylation.
Lohier, J.F. ; Foucoin, F. ; Jaffrès, P.A. ; Garcia, J.I. ; Sopková-de Oliveira Santos, J. ; Perrio, S. ; Metzner, P.
Org. Lett. 2008, 10, 1271-1274, DOI: 10.1021/ol800161m.

Cationic lipids based on phosphonate and phosphoramidate chemistry : synthesis and application to gene therapy.
Mével M., Yaouanc J. J., LaurentP., Clément J. C., CartierD., Jaffrès P. A., Montier T., Delépine P., Le Gall T., LehnP.,Pichon C., Midoux P, C. FérecC.
Phoshorus, Sulfur Silicon Relat. Elem., 2008, 183, 460-468, DOI:10.1080/10426500701761300.

«Synthesis and Transfection Activity of New Cationic Phosphoramidate Lipids: High efficiency of an Imidazolium derivative»
Mével, M. ; Breuzard, G. ; Yaouanc, J. J. ; Clément, J. C. ; Lehn, P. ; Pichon, C. ; Jaffrès, P.A. ; Midoux, P.
ChemBioChem , 2008, 9, 1462-1471, DOI: 10.1002/cbic.200700727.

Fluorescence study of lipid-based DNA carriers properties : influence of cationic lipid chemical structure
Burel-Deschamps, L. ; Ayadi, F. ; Lounissi, S. ; Mével, M. ; Clément, J.C. ; Yaouanc, J.J. ; Jaffrès, P.A. ; Giamarchi, P.
J. Fluoresc., 2008, 18, 835-841, DOI: 10.1007/s10895-008-0312-7.

Polyethylene Nanocomposites based on intercalation of N-alkyl amines within KTiNbO5 Structure Polymer
Chausson, S.; Caignaert, V. ; Retoux, R. ; Rueff, J.-M. ; Le Pluart, L. ; Madec, P.J. ; Jaffrès, P.A.
Polymer, 2008, 49, 488-496, DOI: 10.1016/j.polymer.2007.11.050.

Ethane-1,1,2-trisphosphonic acid hemihydrate
Delain-Bioton, L. ; Lohier, J.F. ; Villemin, D. ; Sopkova, J. ; Hix, G.B. Jaffrès, P.A.
Acta cryst, 2008, C64, o47-o49, DOI:10.1107/S0108270107064098.

Synthesis, crystal structure and thermal properties of phosphorylated cyclotriphosphazenes
Lejeune, N. ; Dez, I. ; Jaffrès, P.A. ; Lohier, J.F. ; Madec, P.J. ; Sopkova-de Oliveira, J.
Eur. J. Inorg. Chem. 2008, 138-143, DOI: 10.1002/ejic.200700785. 


> Publications

  New syntheses of retinal and its acyclic analogy g-retinal by an extended aldol reaction with a C6 building block that incorporates a C5 unit after decarboxylation. A Formal route to lycopene and b-carotene.
A. Valla, B. Valla, R. Le Guillou, D. Cartier, L. Dufossé, R. Labia.
Helvetica Chim. Acta, 2007, 90, 512-520, DOI: 10.1002/hlca.200790053.

A new biomimetic-like aromatization of the cyclic end groups of terpenoids with stereospecific migration of one of the methyl groups : a convenient route to isorenieratene (f,f-carotene).
A. Valla, Z. Andriamialisoa, B. Valla, R. Labia, R. Le Guillou, L. Dufossé, D. Cartier.
Eur. J. Org. Chem., 2007, 711-715, DOI: 10.1002/ejoc.200600794.

New Multidimensional Coordination Polymers with Mu2 and n2 dcno Cyano−carbanions ligands {dcno− = [(NC)2CC(O)O(CH2)2OH]−}
Benmansour, S. ; Setifi, F. ; Triki, S. ; Salaün, J.Y. ; Vandevelde, F. ; Sala−Pala, J. ; Gomez−Garcia, C.J. ; Roisnel, T.
Eur. J. Inorg. Chem. 2007, 186−194, DOI: 10.1002/ejic.200600449.

New Coordination polymers based on a triply bridged dicarboxylate ligand: Synthesis, Structure and Magnetic Properties of the Adipo Complex [Cu4(bipy)4(adip)3](tcnoet)2.2H2O; {bipy = C10H8N2; adip2− = [O2C(CH2)4CO2]2−; tcnoet− = [(CN)2CC(OEt)C(CN)2]− ».
Setifi, F. ; Gomez−Garcia, C.J. ; Marchivie, M. ; Salaün, J.Y. ; Mustapha, M.
Inorg. Chim. Acta 2007, 360, 3879−86, DOI:10.1016/j.ica.2007.03.005.

Status Report on Organo-metallic Beams at GANIL
Lehérissier, P. ; Barué, C. ; Canet, C. ; Dubois, M. ; Dupuis, M. ; Flambard, J.L. ; Jaffrès, P.A. ; .Jardin, P. ; Gaubert, G. ; Lecesne, N. ; Lemagnen, F. ; Leroy, R. ; Pacquet, J.Y.
High Energy Physics And Nuclear Physics, 2007, 31(S1), 85-89.

Synthesis of Triazole-alkyl-phosphonate from ω-Azidoalkylphosphonates and ω-Alkynylphosphonates
Delain-Bioton, L. ; Villemin, D. ; Lohier, J.F. ; Sopkova, J. ;Jaffrès, P.A.
Tetrahedron, 2007, 63, 9677-84, DOI:10.1016/j.tet.2007.07.024.

Dicationic Lipophosphoramidates as DNA carriers
Mével, M. ; Montier, T.; Lamarche, F. ; Delépine, P.; Le Gall, T. ; Yaouanc, J. J.; Jaffrès, P. A. ; Cartier, D.; Lehn, P. ; Clément, J. C.
Bioconjugate Chem., 2007, 18, 1604-1611, DOI: 10.1021/bc070089z.

Lipophosphoramidates as Lipidic Part of Lipospermines for Gene Delivery.
Lamarche F., Mével M., Montier T., Burel-Deschamps L., Giamarchi P., TripierR., Le Gall T., Cartier D., Lehn P., Clément J. C., Jaffrès, P.A.
Bioconjugate Chem. , 2007, 18, 1575-1582, DOI: 10.1021/bc070070w.

A supramolecular ladderlike structure formed by the auto assembly of benzene-1,3,5-triphosphonic acid.
Hix, G.B. ; Caignaert, V. ; Rueff, J.M. ; Le Pluart, L. ; Warren, J.E. ; Jaffrès, P.A.
Crystal Growth & Des., 2007, 7, 208-211, DOI: 10.1021/cg060813k.

Diastereoselective Michael additions to α,β–unsaturated α-sulfinyl phosphonates in the thiolane series
Łyżwa, P. ; Jankowiak, A. ; Kwiatkowska, M. ; Mikołajczyk, M. ; Kiełbasiński, P. ; Betz, A. ; Jaffrès, P.A. ; Gaumont, A.C. ; Gulea, M.
Tetrahedron Lett., 2007, 48, 351-355, DOI:10.1016/j.tetlet.2006.11.098.

N-Heterocyclic Carbene Ligands in Nonsymmetric Diiron Models of Hydrogenase Active Sites.
Morvan, D.; Capon, J.-F.; Gloaguen, F.; Le Goff, A.; Marchivie, M.; Michaud, F.; Schollhammer, P.; Talarmin, J.; Yaouanc, J.-J.; Pichon, R.; Kervarec, N.
Organometallics; 2007; 26, 2042-2052, DOI: 10.1021/om061173l.

w-Alkynes-Mono and Di-phosphonates: Synthesis and Sonogashira Cross Coupling Reaction with Aryl halides.
Delain-Bioton, L. ; Villemin, D. ; Jaffrès, P.A.
Eur. J. Org. Chem., 2007, 1274-1286, DOI: 10.1002/ejoc.200600556.

> Brevet

Nouvelles compositions lipophiles et leurs utilisations
Mével, M. ; Clément, J.C. ; Yaouanc, J.J. ; Pichon, C. ; Midoux, P.
Brevet Français, Fr 07 57955. (28 septembre 2007)

> These

Synthèses de sels d’imidazolium fonctionnalisés précurseurs de carbènes N-hétérocycliques et applications en chimie organométallique. Morvan Didier

Synthèses et études de lipophosphoramidates neutres et cationiques pour la vectorisation de l’ADN. Mével Mathieu