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Plateforme de production
de vecteurs de synthèse
et vectorisation de biomolécules

Publications & Congrès

Articles

2019

2019, 9, 27264 RSC Adv. Model Affitin and PEG modifications onto siRNA lipid nanocapsules : cell uptake and in vivo biodistribution improvements.
Pauline Resnier, Elise Lepeltier, Anthea Lucrezia Emina, Natacha Galopin, Jerome Bejaud, Stephanie David, Caroline Ballet, Thierry Benvegnu, Frederic Pecorari, Igor Chourpa, Jean-Pierre Benoit and Catherine Passirani

2019, Org. Biomol. Chem.
 

2018

2018 12 (10), 9815-9829 ; ACS Nano. Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety
Kevin Van der Jeught, Stefaan De Koker, Lukasz Bialkowski, Carlo Heirman, Patrick Tjok Joe, Federico Perche, Sarah Maenhout, Sanne Bevers, Katrijn Broos, Kim Deswarte, Virginie Malard, Hamida Hammad, Patrick Baril, Thierry Benvegnu, Paul-Alain Jaffrès, Sander A. A. Kooijmans, Raymond Schiffelers, Stefan Lienenklaus, Patrick Midoux, Chantal Pichon, Karine Breckpot, and Kris Thielemans

2018, 536, 29-41 ; J. Control. Release

2018, 278, 110-121 ; ACS Nano
 

2017

2017, 524, 268-278 ; J. Mater. Chem. B

2017, 5, 6869-6881 ; Inter. J. Pharm.

2016

2016, 18, 3-15 ; Org. Biomol. Chem.

2016, 14, 2846-53 ; Org. Biomol. Chem.

2016, 14, 3744-3751 ; Soft Matter

2016, 12, 4516 – 4520 ; Int. J. Pharm

2015

2015, 13, 1122-1132 ; Mol. Pharm.

2015, 12, 1902-1910 ; Biotechnol. J.

2015, 10, 1370–1389 ; Colloids and Surfaces B: Biointerfaces

2015, 136, 192-200 ; Nanomedicine: NBM

2015, 11, 1735–1744 ; Biomaterials

2015, 59, 1-11 ; Inter. J. Mol. Sci.

2015, 16, 26055–26076 ; J. Gene Med

LE CORRE S.S, BELMADI N., BERCHEL M., LE GALL T., HAELTERS J-P., LEHN P., MONTIER T., JAFFRES P-A
Cationic dialkylarylphosphates: new family of bio-inspired cationic lipids for gene delivery.
Organic & Biomolecular Chemistry, 2015, 13, 1122–1132
RASOLONJATOVO B., GOMEZ J-P., MEME W., GONCALVES C., HUIN C., BENNEVAULT-CELTON V., LE GALL T., MONTIER T., LEHN P., CHERADAME H., MIDOUX P., GUEGAN P.
Poly (2-methyl-2-oxazoline)-b-poly(tetrahydrofuran)-b-poly(2-methyl-2-oxazoline) amphiphilic triblock copolymers: synthesis, physicochemical characterizations and hydrosolubilizing properties.
Biomacromolecules, 2015

2014

LE CORRE S.S, BERCHEL M., BELMADI N., DENIS C., HAELTERS J-P., LE GALL T., LEHN P., MONTIER T., JAFFRES P-A.
Cationic lipophosphoramidates with two different lipid chains: synthesis and evaluation as gene carriers.
Organic and Biomolecular Chemistry, 2014, 12(9):1463-74.
LOLLO G., RIVERA-RODRIGUEZ G., BEJAUD J., MONTIER T., PASSIRANI C., BENOIT J- P., GARCÍA-FUENTES M., ALONSO MJ., TORRES D.
Polyglutamic acid-PEG nanocapsules as long circulated carriers for the delivery of docetaxel
European Journal of Pharmaceutics and Biopharmaceutics, 2014, 87(1):47-54.
LE GALL T., POLARD V., ROUSSELOT R., LOTTE R., RAOUANE M., LEHN P., LEIZE E., DEUTSCH E., ZAL F., MONTIER T.
Whole body distribution by fluorescent imaging after single intravenous administration of a new generation of blood substitute and demonstration of its oxygenation potential in mice
Journal of Biotechnology, 2014, 187:1-9.
LE GALL T., BARBEAU J., BARRIER S., BERCHEL M., LEMIÈGRE L., JEFTIĆ J., MERIADEC C., ARTZNER F., LEHN P., JAFFRÈS P-A., BENVEGNU T., MONTIER T.
Impacts of a Novel Archaeal Tetraether-based Colipid on the In Vivo Gene Transfer Activity of Two Cationic Amphiphiles
Molecular Pharmaceutics, 2014, 11(9):2973-88.
LE CORRE S.S., BERCHEL M., LE GALL T., HAELTERS J-P., LEHN P., MONTIER T., JAFFRES P-A.
Cationic trialkylphosphate: synthesis and comparison of transfection efficacies with phosphoramidates analogues.
European Journal of Organic Chemistry, 2014, 36 : 8041-8048
MONTIER T., PICHON C., BLONDEL M., MIDOUX P.
Current status and prospects on nucleic acids transfer (editorial)
Biotechnology Journal, 2014, 9(11):1363-4.

2013

Laurent V, Glaise D, Nubel T, Gilot D, Corlu A, Loyer P. Highly Efficient SiRNA and Gene Transfer into Hepatocyte-Like HepaRG Cells and Primary Human Hepatocytes: New Means for Drug Metabolism and Toxicity Studies. METHODS MOL BIOL, 2013, 987, 295-314.
Loizeau D, Le Gall T, Mahfoudhi S, Berchel M, Maroto A, Yaouanc JJ, Jaffrès PA, Lehn P, Deschamps L, Montier T, Giamarchi P. Physicochemical properties of cationic lipophosphoramidates with an arsonium head group and various lipid chains: a structure-activity approach. Biophysical Chemistry, 2013, 171 : 46 - 53
David S, Passirani C, Carmoy N, Morille M, Mevel M, Chatin B, Benoit JP, Montier T, Pitard B. DNA nanocarriers for systemic administration characterisation and in vivo bioimaging in healthy mice. Molecular Therapy – Nucleic Acids, 2013, 2:e64
Fraix A, Le Gall T, Berchel M, Denis C, Lehn P, Montier T, Jaffrès PA. Cationic lipophosphoramidates with two disulfide motifs: synthesis, behavior in reductive media and gene transfection activity. Organic & Biomolecular Chemistry, 2013, 11(10):1650-8.
Mornet E, Carmoy N, Lainé C, Lemiègre L, Le Gall T, Laurent I, Marianowski R, Férec C, Lehn P, Benvegnu T, Montier T. Folate-equipped nanolipoplexes mediated efficient gene transfer into epithelial cells. International Journal of Molecular Sciences, 2013, 14(1):1477-501.
Le Gall T, Berchel M, Le Hir S, Fraix A, Salaün JY, Férec C, Lehn P, Jaffrès PA, Montier T. Arsonium-Containing Lipophosphoramides, Poly-Functional Nano-Carriers for Simultaneous Antibacterial Action and Eukaryotic Cell Transfection. Advanced Heathcare Materials. 2013doi: 10.1002/adhm.201200478.
Resnier P, Montier T, Mathieu V, Benoit J.P., Passirani C. A review of the current status of siRNA nanomedicines in the treatment of cancer. Biomaterials 2013 34(27):6429-43
Benvegnu T, Lemiègre L, Dalençon S, Jeftic J. Applications of extremophilic archaeal lipids in the field of nanocarriers for oral/topical drug delivery. Current Biotechnology, 2013, 2, 294-303.
RESNIER P., MONTIER T., MATHIEU V, BENOIT JP, PASSIRANI P.
Challenges and opportunities associated with siRNA delivery systems in therapy of cancer.
Biomaterials, 2013, 34(27):6429-43.
RIVERA-RODRIGUEZ G., LOLLO G., MONTIER T., BENOIT JP., PASSIRANI C., ALONSO MJ, TORRES D.
In vivo evaluation of poly-L-asparagine nanocapsules as carriers for anti-cancer drug delivery
International Journal of Pharmaceutics, 2013, 458(1): 83-9.

2012

Josse R, Dumont J, Fautrel A, Robin MA, Guillouzoa. Identification of early target genes of aflatoxin B1 in human hepatocytes, interindividual variability and comparison with other genotoxic compounds. Toxicol Appl Pharmacol, 2012, 258, 176-187.
David S, Carmoy N, Resnier P, Denis C, Misery L, Pitard B, Benoit JP, PassiraniI C, Montier T. In vivo imaging of intravenous administrated DNA LNC in melanoma mice. Int J Pharm. 2012, 423(1) : 108 - 115
Berchel M, Le Gall T, Couthon-Gourvès H, Haelters JP, Montier T, Midoux P, Lehn P, Jaffrès PA. Lipophosphonate/lipophosphoramidates: a family of synthetic vectors efficient for gene delivery. Biochimie., 2012, 94(1): 33-41.
Fraix A, Montier T, Le Gall T, Sevrain C, Carmoy N, Lindberg M, Lehn P, Jaffrès PA. Lipothiophosphoramidate for gene delivery : crititical role of the cationic polar head group. Organic & Biomolecular Chemistry., 2012, 10(10):2051-2058.
Billiet L, Gomez JP, Berchel M, Jaffrès PA, Le Gall T, Montier T, Bertrand E, Cheradame H, Guégan P, Mével M, Pitard B, Benvegnu T, Lehn P, Pichon C, Midoux P. Gene transfer by chemical vectors, and endocytosis routes of polyplexes, lipoplexes and lipopolyplexes in a myoblast cell line. Biomaterials., 2012, 33(10): 2980-90.
Lindberg M, Carmoy N, Le Gall T, Fraix A, Berchel M, Lorilleux C, Couthon-Gourvès H, Bellaud P, Fautrel A, Jaffrès PA, Lehn P, Montier T. The gene transfection properties of a lipophosphoramidate derivative with two phytanyl chains. Biomaterials, 2012, 33(26):6240-53.
David S, Montier T, Carmoy N, Chavreul A, Pitard B, Benoit JP, Passirani C.Treatment efficacy of DNA lipid nanocapsules and DNA multimodular systems after systemic administration in a glioma mouse model. J Gene Med, 2012, 14(12):769-75

2011

Fraix A, Montier T, Carmoy C, Loizeau D, Burel-Deschamps L, Le Gall T, Giamarchi P, Couthon-Gourvès H, Haelters JP, Lehn P, Jaffrès PA. Cationic Lipothiophosphoramidates for in vitro gene delivery: synthesis, physico-chemical characterisations and transfection assays- comparison with lipophosphoramidates. Organic & Biomolecular Chemistry, 2011, 9(7) : 2422 - 2432.
Berchel M, Le Gall T, Denis C, Le Hir S, Quentel F, Elléouet C, Montier T, Rueff JM, Salaün JY, Haelters JP, Hix GB, Lehn P, Jaffrès PA. A silver-based Metal Organic Framework material as a ‘reservoir’ of bactericidal metal ions. New Journal of Chemistry, 2011, 35 : 1000-1003
Huin C, Gall TL, Barteau B, Pitard B, Montier T, Lehn P, Cheradame H, Guégan P. Evidence of DNA Transfer across a Model Membrane by a Neutral Amphiphilic Block Copolymer. J Gene Med., 2011, 13(10) : 538 - 548

2010

Dumont J, Josse R, Lambert C, Antherieu S; Laurent V, Loyer P, Robin MA, Guillouzo A. Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. TOX APPL PHARMACOL, 2010, 249, 91-100.
Morille M, Montier T, Legras P, Carmoy N, Brodin P, Pitard B, Benoit J-P, Passirani C. Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting. Biomaterials, 2010, 31(2):321-329.
Le Gall T, Loizeau D, Picquet E, Carmoy N, Yaouanc JJ, Burel-Deschamps L, Delépine P, Giamarchi P, Jaffrès PA, Lehn P, Montier T. A novel efficient cationic lipophosphoramidate with di-unsaturated lipid chains: synthesis, physico-chemical properties and transfection activities. J Med Chem., 2010, 53(4):1496 - 1508.
Picarda G, Lamoureux F, Geffroy L, Delépine P, Montier T, Laud K, Tirode F, Delattre O, Heymann D, Redini F. Preclinical evidence of using TRAIL in Ewing’s sarcoma therapy: TRAIL inhibits tumor growth, prevents osteolysis and increases animal survival. Cancer Clinical Research, 2010, 16(8):2363 - 2374.
Laurent V, Fraix A, Montier T, Cammas-Marion S, Ribault C, Benvegnu T, Jaffres PA, Loyer P. Highly efficient gene transfer into hepatocyte-like HepaRG cells: New means for drug metabolism and toxicity studies. Biotechnol. J, 2010, 5(3): 314-320.
Loyer P, Busson A, Trembley JH, Hyle J, Grenet J, Zhao W, Ribault C, Montier T, Kidd VJ, Lahti JM. The RNA-Binding Motif protein 15B (RBM15B/OTT3) is a functional competitor of Serine-Arginine (SR) proteins and antagonizes the positive effect of the CDK11p110/cyclin L2α complex on splicing. Journal of Biological Chemistry, 2010, 286(1):147-159
Portier Y, Lainé C, Lemiègre L, Montier T, Cammas-Marion S, Lehn P, Benvegnu T. Folate PEGylated archaeal lipids: cell targeting and drug delivery. J Control Release. 2010, 148(1): 115-116.

2009

Toutrais O, Cabillic F, Le Friec G, Salot S, Loyer P, Le Gallo M, Desille M, Thomas De La Pintiere C, Daniel P, Bouet F, Catros V. Dnax accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by V9V2 T cells. EUR J IMMUNOL, 2009, 39, 1361-1368.
Gamble C, Trotard M, Le Seyec J, Abreu-Guerniou V, Gernigon N, Berree F, Felden B, Gillet R. Antiviral effect of ribonuclease conjugated oligodeoxynucleotides targeting the IRES RNA of the hepatitis C virus. BIOORG MED CHEM LETT, 2009, 19, 3581-3585.
Akhdar H, Loyer P, Rauch C, Corlu A, Guillouzo A, Morel F. Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells. EUR J CANCER, 2009, 12, 2219-2227.
Legendre C, Hori T, Loyer P, Aninat C, Ishida S, Glaise D, Lucas-Clerc C, Boudjema K, Guguen-Guillouzo C, Corlu A, Morel F. Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF1-a involvement in CYP3A4 repression. EUR J CANCER, 2009, 12, 2882-2892.

2008

Loyer P, Trembley JH, Grenet JA, Busson A, Corlu A, Zhao W, Kocak M, Kidd VJ, Lahti JM. Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. J BIOL CHEM, 2008, 283, 7721-7732.

Congrès

Le congrès biotech de Biogenouest

Le projet européen de Biogenouest

Groupe Thématique de Recherche sur la Vectorisation

The American Society of Gene & Cell Therapy