Site Model

Plateforme de production
de vecteurs de synthèse
et vectorisation de biomolécules

Publications & Congrès



  • Resnier P., Lepeltier E., Emina A. Lucrezia Galopin N., Bejaud J., David S., Ballet C., Benvegnu T., Pecorari F., Chourpa I., Benoît J. - P., Passirani-Malleret C. Model Affitin and PEG modifications onto siRNA lipid nanocapsules: cell uptake and in vivo biodistribution improvements. RSC Advances. 2019. 9, 27264-27278.
  • Vlach M, Quesnot N, Dubois-Pot-Schneider H, Ribault C, Verres Y, Petitjean K, Rauch C, Morel F, Robin MA, Corlu A, Loyer P. Cytochrome P450 1A1/2, 2B6 and 3A4 HepaRG Cell-Based Biosensors to Monitor Hepatocyte Differentiation, Drug Metabolism and Toxicity. 2019, 19. pii: E2245. doi: 10.3390/s19102245 Sensors (Basel).
  • A. Bouraoui, M. Berchel, R. Ghanem, V. Vié, G. Paboeuf, L. Deschamps, O. Lozach, T. Le Gall, T. Montier, P.A. Jaffrès. Thiol-ene click reaction to construct the lipid chains of cationic amphiphiles: physico-chemical behaviour and application for gene delivery. Org. Biomol. Chem, 2019, 17, 3609-3616


  • Van der Jeught K, De Koker S, Bialkowski L, Heirman C, Tjok Joe P, Perche F, Maenhout S, Bevers S, Broos K, Deswarte K, Malard V, Hammad H, Baril P, Benvegnu T, Jaffrès PA, Kooijmans SAA, Schiffelers R, Lienenklaus S, Midoux P, Pichon C, Breckpot K, Thielemans K. Systemic delivery of modified mRNA through lipopolyplexes combines strong antitumor T cell immunity with improved inflammatory safety. ACS Nano, 2018, 12, 9815-9829.
  • Mottais A, Berchel M, Sibiril Y, Laurent V, Gill D, Hyde S, Jaffrès PA, Montier T, Le Gall T. Antibacterial effect and DNA delivery using a combination of anarsonium-containing lipophosphoramide with an N-heterocyclic carbene-silver complex - Potential benefits for cystic fibrosis lung gene therapy. Int J Pharm. 2018 Jan 30;536:29-41. doi: 10.1016/j.ijpharm.2017.11.022. Epub 2017 Nov 11.
  • Le Moignic A, Malard V, Benvegnu T, Lemiègre L, Berchel M, Jaffrès PA, Baillou C, Delost M, Macedo R, Rochefort J, Lescaille G, Pichon C, Lemoine FM, Midoux P, Mateo V. Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells. J Control Release. 2018 May 28;278:110-121. doi: 10.1016/j.jconrel.2018.03.035.
  • K. Van der Jeught, S. De Koker, L. Bialkowski, C. Heirman, P. Tjok Joe, S. Bevers, K. Broos, K. Deswarte, V. Malard, H. Hammad, P. Baril, T. Benvegnu, P.A. Jaffrès, S. Kooijmans, R. Schiffelers, S. Lienenklaus, C. Pichon, P. Midoux, K. Breckpot, K. Thielemans. Systemic delivery of modified mRNA through lipopolyplexes combines strong antitumor T cell immunity with improved inflammatory safety. ACS Nano, 2018, 12, 9815-9829
  • Simon Bucher, Dounia Le Guillou, Julien Allard, Grégory Pinon, Karima Begriche, Arnaud Tête, Odile Sergent, Dominique Lagadic-Gossmann, and Bernard Fromenty. Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure. Oxidative Medicine and Cellular Longevity. Volume 2018 | Article ID 4396403


  • Demazeau M, Quesnot N, Ripoche N, Rauch C, Jeftić J, Morel F, Gauffre F, Benvegnu T, Loyer P. Efficient transfection of Xenobiotic Responsive Element-biosensor plasmid using diether lipid and phosphatidylcholine liposomes in differentiated HepaRG cells. Int J Pharm. 2017 May 30;524(1-2):268-278. doi: 10.1016/j.ijpharm. 2017.03.080. Epub 2017 Mar 30.
  • Berchel M, Akhter S, Berthe W, Gonçalves C, Dubuisson M, Pichon C, Jaffrès PA, Midoux P. Synthesis of α-amino-lipophosphonates as cationic lipids or co-lipids for DNA transfection in dendritic cells. J Mater Chem B. 2017 Sep 7;5(33):6869-6881. doi: 10.1039/c7tb01080j. Epub 2017 Aug 4. PubMed PMID: 32264336.


  • M. Berchel, T. Le Gall, O. Lozach, J.P. Haelters, T. Montier, P.A. Jaffrès. Lipophosphoramidate-based bipolar amphiphiles: their syntheses and transfection properties. Org. Biomol. Chem., 2016, 14, 2846-53
  • Delbeke EI, Lozach O, Le Gall T, Berchel M, Montier T, Jaffrès PA, Van Geem KM, Stevens CV. Evaluation of the transfection efficacies of quaternary ammonium prepared from sophorolipid. Org. Biomol. Chem., 2016, 14, 3744-3751.
  • Afonso D, Le Gall T, Couthon-Gourvès H, Grélard A, Prakash S, Berchel M, Kervarec N, Dufourc EJ, Montier T, Jaffrès PA. Triggering bilayer to inverted-hexagonal nanostructure formation by thiol-ene click chemistry on cationic lipids: consequences on gene transfection. Soft Matter. 2016 May 18;12(20):4516-20. doi: 10.1039/c6sm00609d.
  • Jiblaoui A, Barbeau J, Vivès T, Cormier P, Glippa V, Cosson B, Benvegnu T. Folate-conjugated stealth archaeosomes for the targeted delivery of novel antitumoral peptides. RSC ADVANCES, 2016, 6, 75234-75241.


  • Berchel M, Le Gall T, Haelters J.P, Lehn P, Montier T, Jaffrès P.A. Lipophosphoramidates containing cationic hydroxylated polar head group for improving gene delivery. Mol. Pharm., 2015, 12, 1902-1910
  • Le Corre SS, Belmadi N, Berchel M, Le Gall T, Haelters JP, Lehn P, Montier T, Jaffrès PA. Cationic dialkylarylphosphates: a new family of bio-inspired cationic lipids for gene delivery. Org. Biomol. Chem., 2015, 13, 1122-1132
  • Belmani N, Midoux P, Pichon C, Loyer P, Passirani C, Le Gall, T, Jaffrès P.A, Lehn P, Montier T. Synthetic vectors for gene delivery: An overview of their evolution depending on routes of administration. Biotechnol. J., 2015, 10, 1370–1389
  • Loizeau D, Jurkiewicz P, Aydogan G, Philimonenko AA, Mahfoudhi S, Hozák P, Maroto A, Couthon-Gourvès H, Jaffrès PA, Deschamps L, Giamarchi P, Hof M. Biophysical properties of cationic lipophosphoramidates: vesicle morphology, bilayer hydration and lipid mobility. Colloids and Surfaces B: Biointerfaces, 2015, 136, 192-200
  • Lindberg M.F, Le Gall T, Carmoy N, Berchel M, Hyde S.C, Gill D.R, Jaffrès P.A, Lehn P, Montier T. Efficient in vivo transfection and safety profile of a CpG-free and codon optimized luciferaseplasmid using a cationic lipophosphoramidate in a multiple intravenous administration procedure. Biomaterials, 2015, 59, 1-11
  • Belmadi N, Berchel M, Denis C, Berthe W, Sibiril Y, Le Gall T, Haelters J.P, Jaffres P.A and Montier T. Evaluation of New Fluorescent Lipophosphoramidates for Gene Transfer and Biodistribution Studies after Systemic Administration. Int. J. Mol. Sci. 2015, 16(11), 26055-26076;
  • Rasolonjatovo B1, Gomez JP, Même W, Gonçalves C, Huin C, Bennevault-Celton V, Le Gall T, Montier T, Lehn P, Cheradame H, Midoux P, Guégan P. Poly(2-methyl-2-oxazoline)-b-poly(tetrahydrofuran)-b-poly(2-methyl-2-oxazoline) amphiphilic triblock copolymers: synthesis, physicochemical characterizations, and hydrosolubilizing properties. Biomacromolecules. 2015 Mar 9;16(3):748-56. doi: 10.1021/bm5016656. Epub 2015 Feb 5.
  • Gicquel T, Robert S, Loyer P, Victoni T, Bodin A, Ribault C, Gleonnec F, Couillin I, Boichot E, Lagente V. IL1-beta production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages. FASEB J. 2015 Oct;29(10):4162-73.
  • Marivin E, Mourot B, Loyer P, Rime H, Bobe J, Fostier A. Transfection of isolayted rainbow trout, Oncorhynchus mykiss, granulosa cells through chemical transfection and electroporation at 12°C. Gen Comp Endocrinol. 2015 Sep 15;221:165-72.


  • Le Gall T, Polard V, Rousselot M, Lotte A, Raouane M, Lehn P, Opolon P, Leize E, Deutsch E, Zal F, Montier T. In vivo biodistribution and oxygenation potential of a new generation of oxygen carrier. J Biotechnol. 2014 Oct 10;187:1-9. doi: 10.1016/j.jbiotec.2014.07.008. Epub 2014 Jul 15.
  • Le Corre S, Berchel M, Belmadi N, Denis C, Haelters JP, Le Gall T, Lehn P, Montier T and Jaffrès PA. Cationic lipophosphoramidates with two different lipid chains: synthesis and evaluation as gene carriers. Organic and Biomolecular Chemistry, 2014, 12(9):1463-74.
  • Lollo G, Rivera-Rodriguez GR, Bejaud J, Montier T, Passirani C, Benoit JP, García-Fuentes M, Alonso MJ, Torres D. Polyglutamic acid-PEG nanocapsules as long circulated carriers for the delivery of docetaxel. European Journal of Pharmaceutics and Biopharmaceutics, 2014, 87(1):47-54.
  • Le Gall T, Polard V, Rousselot R, Lotte A, Raouane M, Lehn P, Leize E, Deutsch E, Zal F, Montier T. Whole body distribution by fluorescent imaging after single intravenous administration of a new generation of blood substitute and demonstration of its oxygenation potential in mice. Journal of Biotechnology, 2014, 187:1-9.
  • Le Gall T, Barbeau J, Barrier S, Berchel M, Lemiègre L, Jeftić J, Meriadec C, Artzner F, Lehn P, Jaffrès PA, Benvegnu T, Montier T. Impacts of a Novel Archaeal Tetraether-based Colipid on the In Vivo Gene Transfer Activity of Two Cationic Amphiphiles. Molecular Pharmaceutics, 2014, 11(9):2973-88.
  • Le Corre SS, Berchel M, Le Gall T, Haelters JP, Lehn P, Montier T, Jaffrès PA. Cationic trialkylphosphate: synthesis and comparison of transfection efficacies with phosphoramidates analogues. European Journal of Organic Chemistry, 2014, 36 : 8041-8048
  • Montier T, Pichon C, Blondel M, Midoux P. Current status and prospects on nucleic acids transfer (editorial). Biotechnology Journal, 2014, 9(11):1363-4.


  • Laurent V, Glaise D, Nubel T, Gilot D, Corlu A, Loyer P. Highly Efficient SiRNA and Gene Transfer into Hepatocyte-Like HepaRG Cells and Primary Human Hepatocytes: New Means for Drug Metabolism and Toxicity Studies. METHODS MOL BIOL, 2013, 987, 295-314.
  • Loizeau D, Le Gall T, Mahfoudhi S, Berchel M, Maroto A, Yaouanc JJ, Jaffrès PA, Lehn P, Deschamps L, Montier T, Giamarchi P. Physicochemical properties of cationic lipophosphoramidates with an arsonium head group and various lipid chains: a structure-activity approach. Biophysical Chemistry, 2013, 171 : 46 - 53
  • David S, Passirani C, Carmoy N, Morille M, Mevel M, Chatin B, Benoit JP, Montier T, Pitard B. DNA nanocarriers for systemic administration characterisation and in vivo bioimaging in healthy mice. Molecular Therapy – Nucleic Acids, 2013, 2:e64
  • Fraix A, Le Gall T, Berchel M, Denis C, Lehn P, Montier T, Jaffrès PA. Cationic lipophosphoramidates with two disulfide motifs: synthesis, behavior in reductive media and gene transfection activity. Organic & Biomolecular Chemistry, 2013, 11(10):1650-8.
  • Mornet E, Carmoy N, Lainé C, Lemiègre L, Le Gall T, Laurent I, Marianowski R, Férec C, Lehn P, Benvegnu T, Montier T. Folate-equipped nanolipoplexes mediated efficient gene transfer into epithelial cells. International Journal of Molecular Sciences, 2013, 14(1):1477-501.
  • Le Gall T, Berchel M, Le Hir S, Fraix A, Salaün JY, Férec C, Lehn P, Jaffrès PA, Montier T. Arsonium-Containing Lipophosphoramides, Poly-Functional Nano-Carriers for Simultaneous Antibacterial Action and Eukaryotic Cell Transfection. Advanced Heathcare Materials. 2013doi: 10.1002/adhm.201200478.
  • Resnier P, Montier T, Mathieu V, Benoit J.P., Passirani C. A review of the current status of siRNA nanomedicines in the treatment of cancer. Biomaterials 2013 34(27):6429-43
  • Benvegnu T, Lemiègre L, Dalençon S, Jeftic J. Applications of extremophilic archaeal lipids in the field of nanocarriers for oral/topical drug delivery. Current Biotechnology, 2013, 2, 294-303.
  • Resnier P., Montier T, Mathieu V, Benoît JP, Passirani P. Challenges and opportunities associated with siRNA delivery systems in therapy of cancer. Biomaterials, 2013, 34(27):6429-43.
  • Rivera-Rodriguez G, Lollo G, Montier T, Benoît JP, Passirani C, Alonso MJ, Torres D. In vivo evaluation of poly-L-asparagine nanocapsules as carriers for anti-cancer drug delivery. International Journal of Pharmaceutics, 2013, 458(1): 83-9.


  • Josse R, Dumont J, Fautrel A, Robin MA, Guillouzoa. Identification of early target genes of aflatoxin B1 in human hepatocytes, interindividual variability and comparison with other genotoxic compounds. Toxicol Appl Pharmacol, 2012, 258, 176-187.
  • David S, Carmoy N, Resnier P, Denis C, Misery L, Pitard B, Benoit JP, PassiraniI C, Montier T. In vivo imaging of intravenous administrated DNA LNC in melanoma mice. Int J Pharm. 2012, 423(1) : 108 - 115
  • Berchel M, Le Gall T, Couthon-Gourvès H, Haelters JP, Montier T, Midoux P, Lehn P, Jaffrès PA. Lipophosphonate/lipophosphoramidates: a family of synthetic vectors efficient for gene delivery. Biochimie., 2012, 94(1): 33-41.
  • Fraix A, Montier T, Le Gall T, Sevrain C, Carmoy N, Lindberg M, Lehn P, Jaffrès PA. Lipothiophosphoramidate for gene delivery : crititical role of the cationic polar head group. Organic & Biomolecular Chemistry., 2012, 10(10):2051-2058.
  • Billiet L, Gomez JP, Berchel M, Jaffrès PA, Le Gall T, Montier T, Bertrand E, Cheradame H, Guégan P, Mével M, Pitard B, Benvegnu T, Lehn P, Pichon C, Midoux P. Gene transfer by chemical vectors, and endocytosis routes of polyplexes, lipoplexes and lipopolyplexes in a myoblast cell line. Biomaterials., 2012, 33(10): 2980-90.
  • Lindberg M, Carmoy N, Le Gall T, Fraix A, Berchel M, Lorilleux C, Couthon-Gourvès H, Bellaud P, Fautrel A, Jaffrès PA, Lehn P, Montier T. The gene transfection properties of a lipophosphoramidate derivative with two phytanyl chains. Biomaterials, 2012, 33(26):6240-53.
  • David S, Montier T, Carmoy N, Chavreul A, Pitard B, Benoit JP, Passirani C.Treatment efficacy of DNA lipid nanocapsules and DNA multimodular systems after systemic administration in a glioma mouse model. J Gene Med, 2012, 14(12):769-75


  • Fraix A, Montier T, Carmoy C, Loizeau D, Burel-Deschamps L, Le Gall T, Giamarchi P, Couthon-Gourvès H, Haelters JP, Lehn P, Jaffrès PA. Cationic Lipothiophosphoramidates for in vitro gene delivery: synthesis, physico-chemical characterisations and transfection assays- comparison with lipophosphoramidates. Organic & Biomolecular Chemistry, 2011, 9(7) : 2422 - 2432.
  • Berchel M, Le Gall T, Denis C, Le Hir S, Quentel F, Elléouet C, Montier T, Rueff JM, Salaün JY, Haelters JP, Hix GB, Lehn P, Jaffrès PA. A silver-based Metal Organic Framework material as a ‘reservoir’ of bactericidal metal ions. New Journal of Chemistry, 2011, 35 : 1000-1003
  • Huin C, Gall TL, Barteau B, Pitard B, Montier T, Lehn P, Cheradame H, Guégan P. Evidence of DNA Transfer across a Model Membrane by a Neutral Amphiphilic Block Copolymer. J Gene Med., 2011, 13(10) : 538 - 548


  • Dumont J, Josse R, Lambert C, Antherieu S; Laurent V, Loyer P, Robin MA, Guillouzo A. Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. TOX APPL PHARMACOL, 2010, 249, 91-100.
  • Morille M, Montier T, Legras P, Carmoy N, Brodin P, Pitard B, Benoit J-P, Passirani C. Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting. Biomaterials, 2010, 31(2):321-329.
  • Le Gall T, Loizeau D, Picquet E, Carmoy N, Yaouanc JJ, Burel-Deschamps L, Delépine P, Giamarchi P, Jaffrès PA, Lehn P, Montier T. A novel efficient cationic lipophosphoramidate with di-unsaturated lipid chains: synthesis, physico-chemical properties and transfection activities. J Med Chem., 2010, 53(4):1496 - 1508.
  • Picarda G, Lamoureux F, Geffroy L, Delépine P, Montier T, Laud K, Tirode F, Delattre O, Heymann D, Redini F. Preclinical evidence of using TRAIL in Ewing’s sarcoma therapy: TRAIL inhibits tumor growth, prevents osteolysis and increases animal survival. Cancer Clinical Research, 2010, 16(8):2363 - 2374.
  • Laurent V, Fraix A, Montier T, Cammas-Marion S, Ribault C, Benvegnu T, Jaffres PA, Loyer P. Highly efficient gene transfer into hepatocyte-like HepaRG cells: New means for drug metabolism and toxicity studies. Biotechnol. J, 2010, 5(3): 314-320.
  • Loyer P, Busson A, Trembley JH, Hyle J, Grenet J, Zhao W, Ribault C, Montier T, Kidd VJ, Lahti JM. The RNA-Binding Motif protein 15B (RBM15B/OTT3) is a functional competitor of Serine-Arginine (SR) proteins and antagonizes the positive effect of the CDK11p110/cyclin L2α complex on splicing. Journal of Biological Chemistry, 2010, 286(1):147-159
  • Portier Y, Lainé C, Lemiègre L, Montier T, Cammas-Marion S, Lehn P, Benvegnu T. Folate PEGylated archaeal lipids: cell targeting and drug delivery. J Control Release. 2010, 148(1): 115-116.


  • Toutrais O, Cabillic F, Le Friec G, Salot S, Loyer P, Le Gallo M, Desille M, Thomas De La Pintiere C, Daniel P, Bouet F, Catros V. Dnax accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by V9V2 T cells. EUR J IMMUNOL, 2009, 39, 1361-1368.
  • Gamble C, Trotard M, Le Seyec J, Abreu-Guerniou V, Gernigon N, Berree F, Felden B, Gillet R. Antiviral effect of ribonuclease conjugated oligodeoxynucleotides targeting the IRES RNA of the hepatitis C virus. BIOORG MED CHEM LETT, 2009, 19, 3581-3585.
  • Akhdar H, Loyer P, Rauch C, Corlu A, Guillouzo A, Morel F. Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells. EUR J CANCER, 2009, 12, 2219-2227.
  • Legendre C, Hori T, Loyer P, Aninat C, Ishida S, Glaise D, Lucas-Clerc C, Boudjema K, Guguen-Guillouzo C, Corlu A, Morel F. Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF1-a involvement in CYP3A4 repression. EUR J CANCER, 2009, 12, 2882-2892.


  • Loyer P, Trembley JH, Grenet JA, Busson A, Corlu A, Zhao W, Kocak M, Kidd VJ, Lahti JM. Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. J BIOL CHEM, 2008, 283, 7721-7732.


Le congrès biotech de Biogenouest : mardi 17 Novembre 2020 Brest Arena


Le projet européen de Biogenouest

Groupe Thématique de Recherche sur la Vectorisation

The American Society of Gene & Cell Therapy