UMR 1078
Génétique, génomique fonctionnelle
et biotechnologies



Pour toute information sur les publications contactez

2013/2012 / 2011 / 2010/ 2009 / 2008 / 2007 / 2006 / 2005 / 2004 / 2003 / 2002 / 2001 / 2000 / 1999 / 1998 / 1997


  • David S, Passirani C, Carmoy N, Morille M, Mevel M, Chatin B, Benoit JP, Montier T, Pitard B. DNA nanocarriers for systemic administration characterisation and in vivo bioimaging in healthy mice. Molecular Therapy – Nucleic Acids, 2013, 2:e64
  • Mornet E, Carmoy N, Laine C, Lemiegre L, Le Gall T, Laurent I, Marianowski R, Férec C, Lehn P, Benvegnu T, Montier T. Folate-equipped nanolipoplexes mediated efficient gene transfer into human epithelial cells. International Journal of Molecular Sciences, 2013, 14(1):1477-501
  • Fraix A, Le Gall T, Berchel M, Denis C, Lehn P, Montier T, Jaffrès PA. Cationic lipophosphoramidates with two disulfide motifs: synthesis, behavior in reductive media and gene transfection activity.Org Biomol Chem, 2013, in press

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  • David S, Carmoy N, Resnier P, Denis C, Misery L, Pitard B, Benoit JP, Passirani C, Montier T. In vivo imaging of DNA lipid nanocapsules after systemic administration in a melanoma mouse model. Int J Pharm. 2012; 423(1):108-15.
  • Berchel M, Le Gall T, Couthon-Gourves H, Haelters JP, Montier T, Midoux P, Lehn P, Jaffrès PA. Lipophosphonate/lipophosphoramidates: A family of synthetic vectors efficient for gene delivery. Biochimie. 2012 ; 94(1):33-41.
  • Fraix A, Montier T, Le Gall T, Sevrain C, Carmoy N, Lindberg M, Lehn P, Jaffrès PA. Lipothiophosphoramidate for gene delivery : crititical role of the cationic polar head group. Org Biomol Chem., 2012, 10(10):2051-2058.
  • Billiet L, Gomez JP, Berchel M, Jaffrès PA, Le Gall T, Montier T, Bertrand E, Cheradame H, Guégan P, Mével M, Pitard B, Benvegnu T, Lehn P, Pichon C, Midoux P. Gene transfer by chemical vectors, and endocytosis routes of polyplexes, lipoplexes and lipopolyplexes in a myoblast cell line. Biomaterials., 2012, 33(10): 2980-90.
  • Lindberg M, Carmoy N, Le Gall T, Fraix A, Berchel M, Lorilleux C, Couthon-Gourves H, Bellaud P, Fautrel A, Jaffrès PA, Lehn P, Montier T. The gene transfection properties of a lipophosphoramidate derivative with two phytanyl chains. Biomaterials, 2012, 33(26):6240-53.
  • David S, Montier T, Carmoy N, Chavreul A, Pitard B, Benoit JP, Passirani C. Treatment efficacy of DNA lipid nanocapsules and DNA multimodular systems after systemic administration in a glioma mouse model. J Gene Med, 2012, 14(12):769-75
  • Loizeau D, Le Gall T, Mahfoudhi S, Berchel M, Maroto A, Yaouanc JJ, Jaffrès PA, Lehn P, Deschamps L, Montier T, Giamarchi P. Physicochemical properties of cationic lipophosphoramidates with an arsonium head group and various lipid chains: a structure-activity approach. Biophysical Chemistry, 2012, 171:46-53



  • Loyer P, Busson A, Trembley JH, Hyle J, Grenet J, Zhao W, Ribault C, Montier T, Kidd VJ, Lahti JM. The RNA binding motif protein 15B (RBM15B/OTT3) is a functional competitor of serine-arginine (SR) proteins and antagonizes the positive effect of the CDK11p110-cyclin L2α complex on splicing. J Biol Chem. 2011;286(1):147-59.
  • Fraix A, Montier T, Carmoy N, Loizeau D, Burel-Deschamps L, Le Gall T, Giamarchi P, Couthon-Gourves H, Haelters JP, Lehn P, Jaffrès PA. Cationic lipo-thiophosphoramidates for gene delivery: synthesis, physico-chemical characterization and gene transfection activity--comparison with lipo-phosphoramidates. Org Biomol Chem. 2011; 9(7):2422-32.
  • Ianotto JC, Tempescul A, Delepine P, Guillerm G, Hardy E, Eveillard JR, Berthou C. Delayed G-CSF stimulation after PBSCT does not seem to modify the biological parameters of bone marrow recovery. Am J Hematol. 2011; 86(4):351-2.
  • Jaffrès PA, Fraix A, Lorilleux C, Berchel M, Couthon-Gourves H, Haelters JP, Yaouanc JJ, Burel L, Giamarchi P, Midoux P, Montier T, Lehn P. New lipo-phosphoramidates for gene delivery. Phosphorus, Sulfur, silicon and related elements, 2011, 186 (4) : 918-920
  • Berchel M, Le Gall T, Denis C, Le Hir S, Quentel F, Elleouet C, Montier T, Rueff JM, Salaün JY, Haelters JP, Hix GB, Lehn P, Jaffrès PA. A silver-based metal–organic framework material as a ‘reservoir’ of bactericidal metal ions. New J. Chem. 2011; 35:1000-1003.
  • Huin C, Gall TL, Barteau B, Pitard B, Montier T, Lehn P, Cheradame H, Guégan P. Evidence of DNA transfer across a model membrane by a neutral amphiphilic block copolymer. J Gene Med. 2011; 13(10):538-48.



  • Morille M., Montier T, Legras P, Carmoy N, Brodin P, Pitard B, Benoit JP, Passirani C. Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting. Biomaterials, 2010; 31(2):321-9.
  • Le Gall T, Loizeau D, Picquet E, Carmoy N, Yaouanc JJ, Burel-Deschamps L, Delépine P, Giamarchi P, Jaffrès PA, Lehn P, Montier T. A novel efficient cationic lipophosphoramidate with di-unsaturated lipid chains: synthesis, physico-chemical properties and transfection activities. Journal of Medicinal Chemistry, 2010; 53(4):1496-508.
  • Picarda G, Lamoureux F, Geffroy L, Delépine P, Montier T, Laud K, Tirode F, Delattre O, Heymann D, Redini F. Preclinical evidence of using TRAIL in Ewing’s sarcoma therapy: TRAIL inhibits tumor growth, prevents osteolysis and increases animal survival. Cancer Clinical Research, 2010; 16(8):2363-74.
  • Laurent V, Fraix A, Montier T, Cammas-Marion S, Ribault C, Benvegnu T, Jaffrès PA, Loyer P. Highly efficient gene transfer into hepatocyte-like HepaRG cells: New means for drug metabolism and toxicity studies. Biotechnology Journal, 2010; 5(3):314-20.
  • Montier T, Dufour F, Ravilly S, Delpech M, Lehn P. Mucoviscidose : progrès et espoirs. Biofutur 2010 ; 310 :56-61
  • Saada J, Oudrhiri N, Bonnard A, De Lagausie P, Aissaoui A, Hauchecorne M, Oury JF, Aigrain Y, Peuchmaur M, Lehn JM, Lehn P, Luton D. Combining keratinocyte growth factor transfection into the airways and tracheal occlusion in a fetal sheep model of congenital diaphragmatic hernia. J Gene Med. 2010; 12(5):413-22.
  • Jiang X, Forrest D, Nicolini F, Turhan A, Guilhot J, Yip C, Holyoake T, Jorgensen H, Lambie K, Saw KM, Pang E, Vukovic R, Lehn P, Ringrose A, Yu M, Binkman RR, Smith C, Eaves A, Eaves C.  Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate. Blood. 2010;116(12):2112-21.
  • Portier Y, Laine C, Lemiegre L, Montier T, Cammas-Marion S, Lehn P, Benvegnu T. Folate PEGylated archaeal lipids: cell targeting and drug delivery. J Control Release. 2010; 148(1):e115-6.



  • Le Gall T, Baussanne I, Halder S, Carmoy N, Montier T, Lehn P, Decout JL. Synthesis and transfection properties of a series of lipidic neamine derivatives. Bioconjugate Chemistry, 2009; 20(11):2032-46.


  • Mevel M, Yaouanc JJ, Laurent P, Clement JC, Cartier D, Jaffrès PA, Montier T, Delépine P, Le Gall T, Lehn P, Pichon C, Midoux P, Férec C. Cationic Lipids Based on Phosphonate and Phosphoramidate Chemistry: Synthesis and Application to Gene Therapy. Phosphorus, Sulfur, and Silicon and the Related Elements, 2008; 183(2-3):460-468(9)
  • Mevel M, Lamarche F, Clement JC, Yaouanc JJ, Laurent L, Burel L, Giamarchi P, Montier T, Delépine P, Lehn P, Jaffrès PA, Férec C. New Polyamines Phosphoramidate Vectors for Gene Therapy. Phosphorus, Sulfur, and Silicon and the Related Elements, 2008, 183(2):623 – 624
  • Mevel M, Lamarche F, Clement JC, Yaouanc JJ, Laurent L, Burel L, Giamarchi P, Montier T, Delépine P, Lehn P, Jaffrès PA, Férec C. New Phosphoramidate Dicationic Vectors for Gene Therapy Phosphorus, Sulfur, and Silicon and the Related Elements, 2008, 183(2):745 – 746
  • Le Gallo M, Toutirais O, Montier T, Cabillic F, Bouet F, Delépine P, Lehn P, Jotereau F, Catros V. Activation of tumor-specific T cells by dendritic cells expressing the NY-ESO-1 antigen after transfection with the cationic lipophosphoramide KLN5. The Journal of Gene Medicine, 2008; 10(6):628-36.
  • Laine C, Mornet E, Lemiegre L, Montier T, Cammas-Marion S, Neveu C, Carmoy N, Lehn P, Benvegnu T. Folate-equipped pegylated archaeal lipid derivatives: synthesis and transfection properties. Chemistry, a european journal. 2008; 14(27):8330-40.
  • Montier T, Benvegnu T, Jaffrès PA, Yaouanc JJ, Lehn P. Progress in cationic lipid-mediated gene transfection: a series of bio-inspired lipids as an example. Current Gene Therapy, 2008; 8(5):296-312.



  • Rethore G, Montier T, Le Gall T, Delépine P, Cammas-Marion S, Lemiegre L, Lehn P, Benvegnu T. Archaeosomes based on synthetic tetraether-like lipids as novel versatile gene delivery systems. Chemical Communications (Cambridge, England), 2007; 20:2054-6.
  • Lamarche F, Mevel M, Montier T, Burel-Deschamps L, Giamarchi P, Tripier R, Delépine P, Le Gall T, Cartier D, Lehn P, Jaffrès PA, Clement J.C. Lipophosphoramidates as lipidic part of lipospermines for gene delivery. Bioconjugate Chemistry, 2007; 18(5):1575-82.
  • Mevel M, Montier T, Lamarche F, Delépine P, Le Gall T, Yaouanc JJ, Jaffrès PA, Cartier D, Lehn P, Clement JC. Dicationic lipophosphoramidates as DNA carriers. Bioconjugate Chemistry, 2007; 18(5):1604-11.
  • Marcorelles P, Montier T, Gillet D, Lagarde N, Férec C. Evolution of CFTR protein distribution in lung tissue from normal and CF human fetuses. Pediatric Pulmonology, 2007; 42(11):1032-40.



  • Picquet E, Delépine P, Mevel M, Montier T. Synthèse de nouveaux lipides monocationiques – Application en transfert de gènes. Actualité Chimique, 2006 ; 297 :29-32.


  • Picquet E, Le Ny K, Delépine P, Montier T, Yaouanc JJ, Cartier D, Des Abbayes H, Férec C, Clement J.C. Cationic lipophosphoramidates and lipophosphoguanidines are very efficient for in vivo DNA delivery. Bioconjugate Chemistry, 2005; 16(5):1051-3.


  • MONTIER T., DELEPINE P., MARIANOWSKI R., LE NY K., LE BRIS M., GILLET D., POTARD G., MONDINE P., FRACHON I., YAOUANC J.J., CLEMENT J.C., DES ABBAYES H., FEREC C.CFTR transgene expression in primary DeltaF508 epithelial cell cultures from human nasal polyps following gene transfer with cationic phosphonolipids. Molecular Biotechnology, 2004; 26(3):193-206.
  • MONTIER T., DELEPINE P., BENVEGNU T., FERRIERES V., MIRAMON M.L., DAGORN S., GUILLAUME C., PLUSQUELLEC D., FEREC C. Efficient gene transfer into human epithelial cell lines using glycosylated cationic carriers and neutral glycosylated co-lipids. Blood Cells, Molecules and Diseases, 2004; 32(2):271-82.
  • MONTIER T., DELEPINE P., LE NY K., FICHOU Y., LE BRIS M., HARDY E., PICQUET E., CLEMENT J.C., YAOUANC J.J., FEREC C. KLN-5: a safe monocationic lipophosphoramide to transfect efficiently haematopoietic cell lines and human CD34+ cells. Biochimica and Biophysica Acta, 2004; 1665(1-2):118-33.
  • MONTIER T., DELEPINE P., PICHON C., FEREC C., PORTEOUS D.J., MIDOUX P. Non-viral vectors in cystic fibrosis gene therapy: progress and challenges. Trends in Biotechnology, 2004; 22(11):586-92.


  • MONTIER T., CAVALIER A., DELEPINE P., GUILLAUME C., CLEMENT J.C., YAOUANC J.J., MOREL G., THOMAS D., FEREC C. The use of in situ hybridization to study the transgene pathway following cellular transfection with cationic phosphonolipids. Blood Cells, Molecules and Diseases, 2003; 30(1):112-23.
  • DELEPINE P. GUILLAUME C. MONTIER T. CLEMENT J.C., YAOUANC J.J., DES ABBAYES H., BERTHOU F., LE PAPE A., FEREC C. Biodistribution study of phosphonolipids: a class of non-viral vectors efficient in mice lung-directed gene transfer. The Journal of Gene Medicine, 2003. 5(7):600-8.
  • MONTIER T., DELEPINE P., LE NY K., BLANC F., FICHOU Y., LE BRIS M., GILLET D., PIQUET E., CLEMENT J.C., YAOUANC J.J., DES ABBAYES H., FEREC C. Cationic phosphonolipids evolution: a constant and continuous improvement of transfection activity. Recent Res. Devel. Chem., 2003; 1:41-58.
  • DOUCET L., MENDES F., MONTIER T., DELEPINE P., PENQUE D., FEREC C., AMARAL M.D. Applicability of different antibodies for the immunohistochemical localization of CFTR in respiratory and intestinal tissues of human and murine origin. Journal of Histochemistry and Cytochemistry, 2003, 51: 1191-9.



  • VAYSSE L., GUILLAUME C., BURGELIN I., GORRY P., FEREC C., ARVEILER B. Proteolipidic vectors for gene transfer to the lung. Biochemical and Biophysical Research Communications, 2002; 290(5):1489-98.
  • DELEPINE P., MONTIER T., GUILLAUME C., VAYSSE L., LE PAPE A., FEREC C. Visualization of the transgene distribution according to the administration route allows prediction of the transfection efficacy and validation of the results obtained. Gene Therapy, 2002; 9(11):736-9.


  • LOISEL S., LE GALL C., DOUCET L., FEREC C., FLOCH V. Contribution of plasmid DNA to hepatotoxicity after systemic administration of lipoplexes. Human Gene Therapy, 2001 ; 12(6):685-96.
  • GUILLAUME C., DELEPINE P., DROAL C., MONTIER T., TYMEN G., FEREC C. Aerosolization of cationic lipid-DNA complexes: lipoplex characterization and optimization of aerosol delivery conditions. Biochemical and Biophysical Research Communications, 2001; 286(3):464-71.
  • LOISEL S., FLOCH V., LE GALL C., FEREC C. Factors influencing the efficiency of lipoplexes mediated gene transfer in lung after intravenous administration 1. Journal of Liposome Research, 2001; 11(2-3):127-38. 


  • FLOCH V., DELEPINE P., GUILLAUME C., LOISEL S., CHASSE S., LE BOLC'H G., GOBIN E., LEROY J.P., FEREC C. Systemic administration of cationic phosphonolipids/DNA complexes and the relationship between formulation and lung transfection efficiency. Biochimica & Biophysica Acta, 2000; 1464(1):95-103.
  • GUENIN E., HERVE A.C., FLOCH V., LOISEL S., YAOUANC J.J., CLEMENT J.C., FEREC C., DES ABBAYES H. Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good Efficiency and Low Cellular Toxicity. Angewandte Chemie (International ed. in English), 2000; 39(3):629-631.
  • GUILLAUME C., GOBIN E., FLOCH V., LOISEL S., DELEPINE P., MERCIER B., LEROY J.P., FEREC C. Caecum: a potential site for studing gene transfer in vivo. Journal of liposome research, 2000; 10(1):61-71.
  • GUILLAUME C., DELEPINE P., MERCIER B., GOBIN E., LEROY J.P., MORIN V., FEREC C. Phosphonocationic lipids in protein delivery to mice lungs. Journal of Pharmaceutical Sciences, 2000; 89(5):639-45.
  • DELEPINE P., GUILLAUME C., FLOCH V., LOISEL S., YAOUANC J., CLEMENT J., DES ABBAYES H., FEREC C. Cationic phosphonolipids as nonviral vectors: in vitro and in vivo applications. Journal of Pharmaceutical Sciences, 2000; 89(5):629-38.
  • FLOCH V., LOISEL S., GUENIN E., HERVE A.C., CLEMENT J.C., YAOUANC J.J., DES ABBAYES H., FEREC C. Cation substitution in cationic phosphonolipids: a new concept to improve transfection activity and decrease cellular toxicity. Journal of Medecine Chemistry, 2000 ; 43(24):4617-28.


  • Floch V, Audrézet MP, Guillaume C, Gobin E, Le Bolch G, Clement JC, Yaouanc JJ, Des Abbayes H, Mercier B, Leroy JP, Abgrall JF, Férec C. Transgene expression kinetics after transfection with cationic phosphonolipids in hematopoietic non adherent cells. Biochimica & Biophysica Acta, 1998; 1371(1):53-70.
  • Floch V, Legros N, Loisel S, Guillaume C, Guilbot J, Benvegnu T, Ferrieres V, Plusquellec D, Férec C. New biocompatible cationic amphiphiles derivative from glycine betaine: a novel family of efficient nonviral gene transfer agents. Biochemical and Biophysical Research Communications, 1998; 251(1):360-5.
  • Floch V, Le Bolc'h G, Gable-Guillaume C, Le Bris M, Yaouanc JJ, Des Abbayes H, Férec C, Clement JC. Phosphonolipids as non-viral vectors for gene therapy. European Journal of Medicinal Chemistry, 1998; 33:923-934.
  • Guillaume-Gable C, Floch V, Mercier B, Audrézet MP, Gobin E, Le Bolc'h G, Yaouanc JJ, Clement JC, Des Abbayes H, Leroy JP, Morin V, Férec C. Cationic phosphonolipids as nonviral gene transfer agents in the lungs of mice. Human Gene Therapy, 1998; 9(16):2309-19.



  • Floch V, Férec C. Cationic liposomes mediated gene transfer : towards hematologic applications. Drug News & Perspectives, 1997; 10(5):268-175.
  • Floch V, Le Bolc'h G, Audrezet MP, Yaouanc JJ, Clement JC, Des Abbayes H, Mercier B, Abgrall JF, Férec C. Cationic phosphonolipids as non viral vectors for DNA transfection in hematopoietic cell lines and CD34+ cells. Blood Cells, Molecules & Diseases, 1997; 23(1):69-87.
  • Audrezet MP, Le Bolc'h G, Floch V, Yaouanc JJ, Clement JC, Des Abbayes H, Mercier B, Paul A, Férec C. Novel cationic phosphonolipids agents for gene transfer to a cystic fibrosis cell line. Journal of Liposomes research, 1997; 7(2&3): 273-300.