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  • St. Clair EW, Baer AN, Ng WF, Noaiseh G, Baldini C, Tarrant TK, Papas A, Devauchelle-Pensec V, Wang L, Xu W, Pham TH, Sikora K, Rees WA, Alevizos I. CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial. Nat Med |LS|Internet|RS|. 2024 Jun 5. DOI: 10.1038/s41591-024-03009-3


  • Bettacchioli E, Chiche L, Chaussabel D, Cornec D, Jourde-Chiche N, Rinchai D. An interactive web application for exploring systemic lupus erythematosus blood transcriptomic diversity. Database. 2024 May 28;2024:baae045. PMID: 38805754


  • Scaviner J, Bagacean C, Christian B, Renaudineau Y, Mignen O, Abdoul-Azize S. Blocking Orai1 constitutive activity inhibits B-cell cancer migration and synergistically acts with drugs to reduce B-CLL cell survival. Eur J Pharmacol. 2024 May 15;971:176515. PMID: 38547958


  • Iperi C, Fernández-Ochoa Á, Pers JO, Barturen G, Alarcón-Riquelme M, PRECISESADS Flow Cytometry Study Group, PRECISESADS Clinical Consortium, Quirantes-Piné R, Borrás-Linares I, Segura-Carretero A, Cornec D, Bordon A, Jamin C. Integration of multi-omics analysis reveals metabolic alterations of B lymphocytes in systemic lupus erythematosus. Clin Immunol. 2024 May 10;110243. PMID: 38735509


  • Gandolfo S, Bombardieri M, Pers JO, Mariette X, Ciccia F. Precision medicine in Sjögren’s disease. Lancet Rheumatol. 2024 May 6;S2665-9913(24)00039–0. PMID: 38723653

The UMR1227 'B Lymphocytes and Autoimmunity' brings together several clinical entities around the immunology laboratory.

Rheumatology, haematology, nephorology and odontology for a scientific project articulated around two main complementary and interconnected axes: an axis dedicated to the understanding of the mechanisms that govern the functional orientation of B cells in autoimmunity, and a translational axis aiming at developing new tools to improve the efficiency of B-cell targeting immunotherapies, while working on a better stratification of patients, a better understanding of the mode of action of these therapies, and the development of these therapies and innovative therapeutic strategies.

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